Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

Matteo Bassetti; Daniele R. Giacobbe; Antonio Vena; Cecilia Trucchi; Filippo Ansaldi; Massimo Antonelli; Vaclava Adamkova; Cristiano Alicino; Maria-panagiota Almyroudi; Enora Atchade; Anna M. Azzini; Novella Carannante; Alessia Carnelutti; Silvia Corcione; Andrea Cortegiani; George Dimopoulos; Simon Dubler; José L. García-garmendia; Massimo Girardis; Oliver A. Cornely; Stefano Ianniruberto; Bart Jan Kullberg; Katrien Lagrou; Clement Le Bihan; Roberto Luzzati; Manu L. N. G. Malbrain; Maria Merelli; Ana J. Marques; Ignacio Martin-loeches; Alessio Mesini; José-artur Paiva; Maddalena Peghin; Santi Maurizio Raineri; Riina Rautemaa-richardson; Jeroen Schouten; Pierluigi Brugnaro; Herbert Spapen; Polychronis Tasioudis; Jean-françois Timsit; Valentino Tisa; Mario Tumbarello; Charlotte H. S. B. Van Den Berg; Benoit Veber; Mario Venditti; Guillaume Voiriot; Joost Wauters; Philippe Montravers

doi:10.1186/s13054-019-2497-3

Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

Matteo Bassetti, Daniele R. Giacobbe, Antonio Vena, Cecilia Trucchi, Filippo Ansaldi, Massimo Antonelli, Vaclava Adamkova, Cristiano Alicino, Maria-panagiota Almyroudi, Enora Atchade, Anna M. Azzini, Novella Carannante, Alessia Carnelutti, Silvia Corcione, Andrea Cortegiani, George Dimopoulos, Simon Dubler, José L. García-garmendia, Massimo Girardis, Oliver A. CornelyStefano Ianniruberto, Bart Jan Kullberg, Katrien Lagrou, Clement Le Bihan, Roberto Luzzati, Manu L. N. G. Malbrain, Maria Merelli, Ana J. Marques, Ignacio Martin-loeches, Alessio Mesini, José-artur Paiva, Maddalena Peghin, Santi Maurizio Raineri, Riina Rautemaa-richardson, Jeroen Schouten, Pierluigi Brugnaro, Herbert Spapen, Polychronis Tasioudis, Jean-françois Timsit, Valentino Tisa, Mario Tumbarello, Charlotte H. S. B. Van Den Berg, Benoit Veber, Mario Venditti, Guillaume Voiriot, Joost Wauters, Philippe Montravers

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31–8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04–1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24–3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

Original language	English
Journal	Critical Care
Volume	23
Issue number	1
Early online date	14 Jun 2019
DOIs	https://doi.org/10.1186/s13054-019-2497-3
Publication status	Published - 1 Dec 2019

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2497-3

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Bassetti, M., Giacobbe, D. R., Vena, A., Trucchi, C., Ansaldi, F., Antonelli, M., Adamkova, V., Alicino, C., Almyroudi, M., Atchade, E., Azzini, A. M., Carannante, N., Carnelutti, A., Corcione, S., Cortegiani, A., Dimopoulos, G., Dubler, S., García-garmendia, J. L., Girardis, M., ... Montravers, P. (2019). Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project. Critical Care, 23(1). https://doi.org/10.1186/s13054-019-2497-3

@article{adbbafe632204e77879204db9d427bad,

title = "Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project",

abstract = "Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31–8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04–1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24–3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.",

author = "Matteo Bassetti and Giacobbe, {Daniele R.} and Antonio Vena and Cecilia Trucchi and Filippo Ansaldi and Massimo Antonelli and Vaclava Adamkova and Cristiano Alicino and Maria-panagiota Almyroudi and Enora Atchade and Azzini, {Anna M.} and Novella Carannante and Alessia Carnelutti and Silvia Corcione and Andrea Cortegiani and George Dimopoulos and Simon Dubler and Garc{\'i}a-garmendia, {Jos{\'e} L.} and Massimo Girardis and Cornely, {Oliver A.} and Stefano Ianniruberto and Kullberg, {Bart Jan} and Katrien Lagrou and {Le Bihan}, Clement and Roberto Luzzati and Malbrain, {Manu L. N. G.} and Maria Merelli and Marques, {Ana J.} and Ignacio Martin-loeches and Alessio Mesini and Jos{\'e}-artur Paiva and Maddalena Peghin and Raineri, {Santi Maurizio} and Riina Rautemaa-richardson and Jeroen Schouten and Pierluigi Brugnaro and Herbert Spapen and Polychronis Tasioudis and Jean-fran{\c c}ois Timsit and Valentino Tisa and Mario Tumbarello and {Van Den Berg}, {Charlotte H. S. B.} and Benoit Veber and Mario Venditti and Guillaume Voiriot and Joost Wauters and Philippe Montravers",

year = "2019",

month = dec,

day = "1",

doi = "10.1186/s13054-019-2497-3",

language = "English",

volume = "23",

journal = "Critical Care",

issn = "1364-8535",

publisher = "Springer Nature",

number = "1",

}

Bassetti, M, Giacobbe, DR, Vena, A, Trucchi, C, Ansaldi, F, Antonelli, M, Adamkova, V, Alicino, C, Almyroudi, M, Atchade, E, Azzini, AM, Carannante, N, Carnelutti, A, Corcione, S, Cortegiani, A, Dimopoulos, G, Dubler, S, García-garmendia, JL, Girardis, M, Cornely, OA, Ianniruberto, S, Kullberg, BJ, Lagrou, K, Le Bihan, C, Luzzati, R, Malbrain, MLNG, Merelli, M, Marques, AJ, Martin-loeches, I, Mesini, A, Paiva, J, Peghin, M, Raineri, SM, Rautemaa-richardson, R, Schouten, J, Brugnaro, P, Spapen, H, Tasioudis, P, Timsit, J, Tisa, V, Tumbarello, M, Van Den Berg, CHSB, Veber, B, Venditti, M, Voiriot, G, Wauters, J & Montravers, P 2019, 'Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project', Critical Care, vol. 23, no. 1. https://doi.org/10.1186/s13054-019-2497-3

TY - JOUR

T1 - Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

AU - Bassetti, Matteo

AU - Giacobbe, Daniele R.

AU - Vena, Antonio

AU - Trucchi, Cecilia

AU - Ansaldi, Filippo

AU - Antonelli, Massimo

AU - Adamkova, Vaclava

AU - Alicino, Cristiano

AU - Almyroudi, Maria-panagiota

AU - Atchade, Enora

AU - Azzini, Anna M.

AU - Carannante, Novella

AU - Carnelutti, Alessia

AU - Corcione, Silvia

AU - Cortegiani, Andrea

AU - Dimopoulos, George

AU - Dubler, Simon

AU - García-garmendia, José L.

AU - Girardis, Massimo

AU - Cornely, Oliver A.

AU - Ianniruberto, Stefano

AU - Kullberg, Bart Jan

AU - Lagrou, Katrien

AU - Le Bihan, Clement

AU - Luzzati, Roberto

AU - Malbrain, Manu L. N. G.

AU - Merelli, Maria

AU - Marques, Ana J.

AU - Martin-loeches, Ignacio

AU - Mesini, Alessio

AU - Paiva, José-artur

AU - Peghin, Maddalena

AU - Raineri, Santi Maurizio

AU - Rautemaa-richardson, Riina

AU - Schouten, Jeroen

AU - Brugnaro, Pierluigi

AU - Spapen, Herbert

AU - Tasioudis, Polychronis

AU - Timsit, Jean-françois

AU - Tisa, Valentino

AU - Tumbarello, Mario

AU - Van Den Berg, Charlotte H. S. B.

AU - Veber, Benoit

AU - Venditti, Mario

AU - Voiriot, Guillaume

AU - Wauters, Joost

AU - Montravers, Philippe

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31–8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04–1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24–3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

AB - Background The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02–1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31–8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04–1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24–3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

U2 - 10.1186/s13054-019-2497-3

DO - 10.1186/s13054-019-2497-3

M3 - Article

SN - 1364-8535

VL - 23

JO - Critical Care

JF - Critical Care

IS - 1

ER -

Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

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