Incidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England

Richard Mcnally, Richard J Q McNally, Jillian M. Birch, G. Malcolm Taylor, Osborn B. Eden

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A temporal increase in the incidence of childhood acute lymphoblastic leukaemia (ALL) in the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the increase is a result of an increase in the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual increase in precursor B-cell ALL between 1980 and 1998 was 3.0% (p = 0.024). Recent findings are consistent with the causal involvement of infections in precursor B-cell ALL.
    Original languageEnglish
    Pages (from-to)485-486
    Number of pages1
    JournalThe Lancet
    Volume356
    Issue number9228
    Publication statusPublished - 5 Aug 2000

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