Incidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England

Richard Mcnally; Richard J Q McNally; Jillian M. Birch; G. Malcolm Taylor; Osborn B. Eden

Incidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England

Richard Mcnally, Richard J Q McNally, Jillian M. Birch, G. Malcolm Taylor, Osborn B. Eden

Research output: Contribution to journal › Article › peer-review

Abstract

A temporal increase in the incidence of childhood acute lymphoblastic leukaemia (ALL) in the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the increase is a result of an increase in the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual increase in precursor B-cell ALL between 1980 and 1998 was 3.0% (p = 0.024). Recent findings are consistent with the causal involvement of infections in precursor B-cell ALL.

Original language	English
Pages (from-to)	485-486
Number of pages	1
Journal	The Lancet
Volume	356
Issue number	9228
Publication status	Published - 5 Aug 2000

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title = "Incidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England",

abstract = "A temporal increase in the incidence of childhood acute lymphoblastic leukaemia (ALL) in the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the increase is a result of an increase in the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual increase in precursor B-cell ALL between 1980 and 1998 was 3.0% (p = 0.024). Recent findings are consistent with the causal involvement of infections in precursor B-cell ALL.",

author = "Richard Mcnally and McNally, {Richard J Q} and Birch, {Jillian M.} and Taylor, {G. Malcolm} and Eden, {Osborn B.}",

year = "2000",

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pages = "485--486",

journal = "The Lancet",

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T1 - Incidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England

AU - Mcnally, Richard

AU - McNally, Richard J Q

AU - Birch, Jillian M.

AU - Taylor, G. Malcolm

AU - Eden, Osborn B.

PY - 2000/8/5

Y1 - 2000/8/5

N2 - A temporal increase in the incidence of childhood acute lymphoblastic leukaemia (ALL) in the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the increase is a result of an increase in the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual increase in precursor B-cell ALL between 1980 and 1998 was 3.0% (p = 0.024). Recent findings are consistent with the causal involvement of infections in precursor B-cell ALL.

AB - A temporal increase in the incidence of childhood acute lymphoblastic leukaemia (ALL) in the UK has been noted. We present data from the Manchester Children's Tumour Registry which provide strong evidence that the increase is a result of an increase in the precursor B-cell subtype. In the childhood peak (age 1-4 years), the annual increase in precursor B-cell ALL between 1980 and 1998 was 3.0% (p = 0.024). Recent findings are consistent with the causal involvement of infections in precursor B-cell ALL.

M3 - Article

SN - 0140-6736

VL - 356

SP - 485

EP - 486

JO - The Lancet

JF - The Lancet

IS - 9228

ER -

Incidence of childhood precursor B-cell acute lymphoblastic leukaemia in north-west England

Abstract

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