@article{9e505fce1a774b9db7d92dcfd7c0dfe2,
title = "Incidental findings in low dose CT lung cancer screening of high-risk smokers: Results from the Manchester lung Health Check pilot",
abstract = "Here we report the prevalence of incidental findings (IF) in the Manchester Lung Health Check pilot, which delivered mobile low-dose CT targeted lung cancer screening. 187 IFs were reported in 158 participants (11.2 % of individuals screened; n = 1,409). 101 IFs in 90 participants (6.4 %) were concerning for extra-pulmonary malignancy. IFs resulted in 118 imaging studies, 20 invasive investigations, and 106 new diagnoses, including 5 malignancies (0.35 %). Clinical management of IFs required 84 specialist reviews (6.0 %), 34 medication changes (2.4 %) and 10 interventional treatments (0.71 %). Lung cancer screening detects clinically relevant IFs but further research is needed to better understand the potential benefits and harms of such findings to participants.",
keywords = "Computed tomography, Incidental findings, Lung cancer screening, Screening harms, Early Detection of Cancer/methods, Lung Neoplasms/diagnostic imaging, Smokers, Tomography, X-Ray Computed/methods, Humans, Lung, Incidental Findings, Mass Screening/methods",
author = "P. Goodley and Bola, {B. M.} and H. Balata and A. Sharman and R. Booton and Crosbie, {P. A.J.}",
note = "Funding Information: The pilot was supported by funding from Macmillan Cancer Support. The Macmillan Cancer Improvement Partnership facilitated the design and development of the pilot. The service was delivered by the lung cancer team at Wythenshawe Hospital, Manchester University NHS Foundation Trust, in partnership with Alliance Medical. LDCT reporting was performed by a consortium of NHS consultant radiologists with subspeciality interest in thoracic medicine. The pilot service was commissioned by South Manchester Clinical Commissioning Group on behalf of the three Manchester Clinical Commissioning Groups. Community engagement was delivered by multiple members of the team and was led by MCIP and the Manchester CCGs in conjunction with Manchester City Council, Macmillan Cancer Support and BHA for Equality. Funding Information: The authors would like to thank members of the Manchester Lung Health Check group for their contribution. Members of the group include: P Barber, D Colligan, R Duerden, P Elton, M Evison, M Greaves, J Howells, K Irion, D Karunaratne, S Mellor, T Newton, R Sawyer, E Smith, B Taylor, S Taylor, J Tonge, A Walsham, J Whittaker. The pilot was supported by funding from Macmillan Cancer Support. The Macmillan Cancer Improvement Partnership facilitated the design and development of the pilot. The service was delivered by the lung cancer team at Wythenshawe Hospital, Manchester University NHS Foundation Trust, in partnership with Alliance Medical. LDCT reporting was performed by a consortium of NHS consultant radiologists with subspeciality interest in thoracic medicine. The pilot service was commissioned by South Manchester Clinical Commissioning Group on behalf of the three Manchester Clinical Commissioning Groups. Community engagement was delivered by multiple members of the team and was led by MCIP and the Manchester CCGs in conjunction with Manchester City Council, Macmillan Cancer Support and BHA for Equality. All individuals provided written informed consent to study participation (REC Ref: 17/EE/0092). Clinical data from the screening service was recorded on an ethically approved database (REC Ref: 16/NW/ 0013). Publisher Copyright: {\textcopyright} 2022 The Author(s)",
year = "2022",
month = nov,
day = "1",
doi = "10.1016/j.lungcan.2022.08.017",
language = "English",
volume = "173",
pages = "1--4",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier BV",
}
