Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Barry W. McColl; Nicola Rose; Fiona H. Robson; Nancy J. Rothwell; Catherine B. Lawrence

doi:10.1038/jcbfm.2009.217

Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Barry W. McColl, Nicola Rose, Fiona H. Robson, Nancy J. Rothwell, Catherine B. Lawrence

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Abstract

Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. © 2010 ISCBFM All rights reserved.

Original language	English
Pages (from-to)	267-272
Number of pages	5
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	30
Issue number	2
DOIs	https://doi.org/10.1038/jcbfm.2009.217
Publication status	Published - Feb 2010

Keywords

Blood-brain barrier
Haemorrhagic transformation
Leptin
MMP-9
Obesity
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/jcbfm.2009.217

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title = "Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke",

abstract = "Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. {\textcopyright} 2010 ISCBFM All rights reserved.",

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author = "McColl, {Barry W.} and Nicola Rose and Robson, {Fiona H.} and Rothwell, {Nancy J.} and Lawrence, {Catherine B.}",

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AU - Rose, Nicola

AU - Robson, Fiona H.

AU - Rothwell, Nancy J.

AU - Lawrence, Catherine B.

N1 - , Medical Research Council, United Kingdom

PY - 2010/2

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N2 - Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. © 2010 ISCBFM All rights reserved.

AB - Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. © 2010 ISCBFM All rights reserved.

KW - Blood-brain barrier

KW - Haemorrhagic transformation

KW - Leptin

KW - MMP-9

KW - Obesity

KW - Stroke

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DO - 10.1038/jcbfm.2009.217

M3 - Article

C2 - 19826431

SN - 1559-7016

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SP - 267

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JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

IS - 2

ER -

Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Abstract

Keywords

UN SDGs

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