Increased Circulating Insulin-like Growth Factor-1 in Late-onset Alzheimer's Disease

E R Vardy, P J Rice, P C Bowie, J D Holmes, P J Grant, N M Hooper

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Insulin-like growth factor (IGF)-1 has been implicated in the pathogenesis of Alzheimer's disease (AD). Methods: We compared the level of circulating total and bioavailable IGF-1, by simultaneous measurements of IGF-1 and IGF binding protein (IGFBP)-3, between 87 patients diagnosed with AD and 126 age and sex matched control subjects without cognitive impairment. Blood samples were collected and IGF-1 and IGFBP-3 measured by ELISA. Subjects were also genotyped for apolipoprotein E. Results: Total circulating IGF-1 levels were significantly raised in the AD group as compared to the control group (p=0.022). There was no significant difference in the circulating level of IGFBP-3 between the two groups. When the IGF-1 levels were ratioed against IGFBP-3 levels as an indicator of unbound, bioavailable circulating IGF-1, there was a significant increase in the molar IGF-1:IGFBP-3 ratio in the AD subjects (0.181 +/- 0.006) as compared to the controls (0.156 +/- 0.004) (p<0.001). Logistic regression analysis revealed that an increase in the IGF-1:IGFBP-3 molar ratio increased the risk of AD significantly. Conclusion: The results of increased total and free circulating IGF-1 support the hypothesis that in its early stages late-onset AD reflects a state of resistance to IGF-1.
    Original languageEnglish
    Pages (from-to)285-90
    Number of pages194
    JournalJ Alzheimers Dis
    Volume12
    Issue number4
    Publication statusPublished - 2007

    Research Beacons, Institutes and Platforms

    • Dementia@Manchester

    Fingerprint

    Dive into the research topics of 'Increased Circulating Insulin-like Growth Factor-1 in Late-onset Alzheimer's Disease'. Together they form a unique fingerprint.

    Cite this