Increased density of entorhinal glutamate-immunoreactive vertical fibers in schizophrenia

D Longson, J F Deakin, F M Benes

Research output: Contribution to journalArticlepeer-review


Gluatamtergic fibers have been immunocytochemically localized in the entorhinal cortex of postmortem schizophrenic brains. The density of small caliber vertical fibers was higher in schizophrenics than controls, with no significant increase in the number of large caliber fibers. Increased glutamatergic fiber density has been previously reported in the cingulate cortex. It is proposed that increases in glutamatergic fibers from the amygdala may be responsible for these changes and that they may play a central role in the pathophysiology of schizophrenia.

Original languageEnglish
Pages (from-to)503-7
Number of pages5
JournalJournal of Neural transmission
Issue number4
Publication statusPublished - 1996


  • Cadaver
  • Entorhinal Cortex
  • Glutamic Acid
  • Humans
  • Immunohistochemistry
  • Nerve Fibers
  • Reference Values
  • Regression Analysis
  • Schizophrenia
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.


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