Increased hyaluronate synthesis and changes in glycosaminoglycan ratios and molecular weight of proteoglycans synthesised by cultured cervical tissue from ewes at various stages of pregnancy

John C. Anderson; John G. Raynes; R. J. Fitzpatrick; Hilary Dobson

Increased hyaluronate synthesis and changes in glycosaminoglycan ratios and molecular weight of proteoglycans synthesised by cultured cervical tissue from ewes at various stages of pregnancy

John C. Anderson, John G. Raynes, R. J. Fitzpatrick, Hilary Dobson

Research output: Contribution to journal › Article › peer-review

Abstract

Culture of cervical tissue with radiolabelled precursors showed that, in pregnant ewes, net hyaluronate synthesis increased between days 120-140 but that the marked polydispersity of hyaluronate remained unchanged. In the less sulphated of two proteoglycan populations, the proportion of heparan sulphate increased and that of dermatan sulphate decreased, while the less polydisperse more highly sulphated species showed a significant increase in molecular weight with pregnancy. © 1991.

Original language	English
Pages (from-to)	187-190
Number of pages	3
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	1075
Issue number	2
Publication status	Published - 10 Oct 1991

Keywords

(Ewe)
Cervix
Hyaluronate
Pregnancy
Proteoglycan

Cite this

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title = "Increased hyaluronate synthesis and changes in glycosaminoglycan ratios and molecular weight of proteoglycans synthesised by cultured cervical tissue from ewes at various stages of pregnancy",

abstract = "Culture of cervical tissue with radiolabelled precursors showed that, in pregnant ewes, net hyaluronate synthesis increased between days 120-140 but that the marked polydispersity of hyaluronate remained unchanged. In the less sulphated of two proteoglycan populations, the proportion of heparan sulphate increased and that of dermatan sulphate decreased, while the less polydisperse more highly sulphated species showed a significant increase in molecular weight with pregnancy. {\textcopyright} 1991.",

keywords = "(Ewe), Cervix, Hyaluronate, Pregnancy, Proteoglycan",

author = "Anderson, {John C.} and Raynes, {John G.} and Fitzpatrick, {R. J.} and Hilary Dobson",

year = "1991",

month = oct,

day = "10",

language = "English",

volume = "1075",

pages = "187--190",

journal = "Biochimica et Biophysica Acta - General Subjects",

issn = "1872-8006",

publisher = "Elsevier BV",

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Increased hyaluronate synthesis and changes in glycosaminoglycan ratios and molecular weight of proteoglycans synthesised by cultured cervical tissue from ewes at various stages of pregnancy. / Anderson, John C.; Raynes, John G.; Fitzpatrick, R. J. et al.
In: Biochimica et Biophysica Acta - General Subjects, Vol. 1075, No. 2, 10.10.1991, p. 187-190.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Increased hyaluronate synthesis and changes in glycosaminoglycan ratios and molecular weight of proteoglycans synthesised by cultured cervical tissue from ewes at various stages of pregnancy

AU - Anderson, John C.

AU - Raynes, John G.

AU - Fitzpatrick, R. J.

AU - Dobson, Hilary

PY - 1991/10/10

Y1 - 1991/10/10

N2 - Culture of cervical tissue with radiolabelled precursors showed that, in pregnant ewes, net hyaluronate synthesis increased between days 120-140 but that the marked polydispersity of hyaluronate remained unchanged. In the less sulphated of two proteoglycan populations, the proportion of heparan sulphate increased and that of dermatan sulphate decreased, while the less polydisperse more highly sulphated species showed a significant increase in molecular weight with pregnancy. © 1991.

AB - Culture of cervical tissue with radiolabelled precursors showed that, in pregnant ewes, net hyaluronate synthesis increased between days 120-140 but that the marked polydispersity of hyaluronate remained unchanged. In the less sulphated of two proteoglycan populations, the proportion of heparan sulphate increased and that of dermatan sulphate decreased, while the less polydisperse more highly sulphated species showed a significant increase in molecular weight with pregnancy. © 1991.

KW - (Ewe)

KW - Cervix

KW - Hyaluronate

KW - Pregnancy

KW - Proteoglycan

M3 - Article

C2 - 0001932074

SN - 1872-8006

VL - 1075

SP - 187

EP - 190

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

IS - 2

ER -

Increased hyaluronate synthesis and changes in glycosaminoglycan ratios and molecular weight of proteoglycans synthesised by cultured cervical tissue from ewes at various stages of pregnancy

Abstract

Keywords

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