Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum.

Arjun K Ravi, Shruti Khurana, Jonathan Lemon, Jonathan Plumb, George Booth, Louise Healy, Matthew Catley, Jørgen Vestbo, Dave Singh, Sukh Singh

    Research output: Contribution to journalArticlepeer-review


    BACKGROUND: COPD patients have increased numbers of macrophages and neutrophils in the lungs. Interleukin-6 (IL-6) trans-signaling via its soluble receptor sIL-6R, governs the influx of innate immune cells to inflammatory foci through regulation of the chemokine CCL3. We hypothesized that there would be enhanced levels of IL-6, sIL-6R and CCL3 in COPD sputum. METHODS: 59 COPD patients, 15 HNS and 15 S underwent sputum induction and processing with phosphate buffered saline to obtain supernatants for IL-6, sIL-6R and CCL3 analysis. Cytoslides were produced for differential cell counting and immunocytochemistry (COPD; n = 3) to determine cell type surface expression of the CCL3 receptors CCR5 and CCR1. RESULTS: COPD patients expressed higher levels (p 
    Original languageEnglish
    Article number103
    JournalRespiratory research
    Issue number1
    Publication statusPublished - 2014


    • CCL3
    • COPD
    • Interleukin-6
    • sIL-6R
    • Sputum
    • Two-step sputum processing


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