Increasing growth with raised circulating somatomedin but normal immunoassayable growth hormone

R Hoffenberg; A Howell; S Epstein; B L Pimstone; L Fryklund; K Hall; S Schwalbe; B T Rudd

Increasing growth with raised circulating somatomedin but normal immunoassayable growth hormone

R Hoffenberg, A Howell, S Epstein, B L Pimstone, L Fryklund, K Hall, S Schwalbe, B T Rudd

Division of Cancer Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

Two patients are described with elevation of circulating somatomedin A concentration but normal growth hormone levels. One,a young male, appeared clinically acromegalic; the other, a young female, was tall with kyphoscoliosis, and her appearance resembled Marfan's syndrome. In both patients plasma growth hormone concentration was suppressible by hyperglycaemia. It is suggested that their clinical syndromes resulted from excessive somatomedin activity.

Original language	English
Pages (from-to)	443-448
Number of pages	6
Journal	Clinical Endocrinology
Volume	6
Issue number	6
Publication status	Published - Jun 1977

Keywords

Acromegaly
Female
Growth Disorders
Growth Hormone
Humans
Male
Marfan Syndrome
Somatomedins
Case Reports
Journal Article

Cite this

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title = "Increasing growth with raised circulating somatomedin but normal immunoassayable growth hormone",

abstract = "Two patients are described with elevation of circulating somatomedin A concentration but normal growth hormone levels. One,a young male, appeared clinically acromegalic; the other, a young female, was tall with kyphoscoliosis, and her appearance resembled Marfan's syndrome. In both patients plasma growth hormone concentration was suppressible by hyperglycaemia. It is suggested that their clinical syndromes resulted from excessive somatomedin activity.",

keywords = "Acromegaly, Female, Growth Disorders, Growth Hormone, Humans, Male, Marfan Syndrome, Somatomedins, Case Reports, Journal Article",

author = "R Hoffenberg and A Howell and S Epstein and Pimstone, {B L} and L Fryklund and K Hall and S Schwalbe and Rudd, {B T}",

year = "1977",

month = jun,

language = "English",

volume = "6",

pages = "443--448",

journal = "Clinical Endocrinology",

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TY - JOUR

T1 - Increasing growth with raised circulating somatomedin but normal immunoassayable growth hormone

AU - Hoffenberg, R

AU - Howell, A

AU - Epstein, S

AU - Pimstone, B L

AU - Fryklund, L

AU - Hall, K

AU - Schwalbe, S

AU - Rudd, B T

PY - 1977/6

Y1 - 1977/6

N2 - Two patients are described with elevation of circulating somatomedin A concentration but normal growth hormone levels. One,a young male, appeared clinically acromegalic; the other, a young female, was tall with kyphoscoliosis, and her appearance resembled Marfan's syndrome. In both patients plasma growth hormone concentration was suppressible by hyperglycaemia. It is suggested that their clinical syndromes resulted from excessive somatomedin activity.

AB - Two patients are described with elevation of circulating somatomedin A concentration but normal growth hormone levels. One,a young male, appeared clinically acromegalic; the other, a young female, was tall with kyphoscoliosis, and her appearance resembled Marfan's syndrome. In both patients plasma growth hormone concentration was suppressible by hyperglycaemia. It is suggested that their clinical syndromes resulted from excessive somatomedin activity.

KW - Acromegaly

KW - Female

KW - Growth Disorders

KW - Growth Hormone

KW - Humans

KW - Male

KW - Marfan Syndrome

KW - Somatomedins

KW - Case Reports

KW - Journal Article

M3 - Article

C2 - 884876

SN - 0300-0664

VL - 6

SP - 443

EP - 448

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 6

ER -

Increasing growth with raised circulating somatomedin but normal immunoassayable growth hormone

Abstract

Keywords

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