TY - JOUR
T1 - Incremental and decremental L- and M-cone-driven ERG responses: I. Square-wave pulse stimulation
AU - McKeefry, Declan
AU - Kremers, Jan
AU - Kommanapalli, Deepika
AU - Challa, Naveen K.
AU - Murray, Ian J.
AU - Maguire, John
AU - Parry, Neil R A
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Electroretinograms (ERGs) elicited by transient, square-wave L- and M-cone isolating stimuli were recorded from human trichromatic (n - 19) and dichromatic (n - 4) observers. The stimuli were generated on a four primary LED stimulator and were equated in terms of cone modulation (cone contrast - 0.11) and retinal illuminance (12,000 trolands). L- and M-cone isolated ERGs had waveforms similar to those observed for luminance responses. However, M-cone ERGs exhibited a phase reversal in their responses to onset and offset stimuli relative to the L-cone responses. This on-off response reversal was observed in trichromats but not dichromats. Simultaneous counterphase and inphase combinations of L- and M-cone isolating stimuli generated responses that reflected chromatic and luminance processing, respectively. We conclude that L- and M-cone specific ERGs provide a measure of how photoreceptors contribute to postreceptoral mechanisms. © 2014 Optical Society of America.
AB - Electroretinograms (ERGs) elicited by transient, square-wave L- and M-cone isolating stimuli were recorded from human trichromatic (n - 19) and dichromatic (n - 4) observers. The stimuli were generated on a four primary LED stimulator and were equated in terms of cone modulation (cone contrast - 0.11) and retinal illuminance (12,000 trolands). L- and M-cone isolated ERGs had waveforms similar to those observed for luminance responses. However, M-cone ERGs exhibited a phase reversal in their responses to onset and offset stimuli relative to the L-cone responses. This on-off response reversal was observed in trichromats but not dichromats. Simultaneous counterphase and inphase combinations of L- and M-cone isolating stimuli generated responses that reflected chromatic and luminance processing, respectively. We conclude that L- and M-cone specific ERGs provide a measure of how photoreceptors contribute to postreceptoral mechanisms. © 2014 Optical Society of America.
U2 - 10.1364/JOSAA.31.00A159
DO - 10.1364/JOSAA.31.00A159
M3 - Article
SN - 1084-7529
VL - 31
SP - A159-A169
JO - Optical Society of America. Journal A: Optics, Image Science, and Vision
JF - Optical Society of America. Journal A: Optics, Image Science, and Vision
IS - 4
ER -