Indications for the use of bronchial thermoplasty in severe asthma.

Keertan Dheda, Coenraad F N Koegelenberg, Aliasgar Esmail, Elvis Irusen, Michael E Wechsler, Rob M Niven, Kian Fan Chung, Eric D Bateman

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Approximately 5% of the ~3 million asthmatics in South Africa have severe asthma that is associated with substantial morbidity, cost, absenteeism, preventable mortality, and the requirement for costly chronic medication that may be associated with significant adverse events. There is an unmet need for alternative safer and more effective interventions for severe asthma. A recently introduced option, bronchial thermoplasty (BT), imparts radiofrequency-generated heat energy to the airways to cause regression of airway smooth muscle. The effectiveness of this technique has been confirmed in randomised control trials and is now endorsed by several international guidelines, including the Global Initiative for Asthma (GINA) guideline, the British Asthma Guideline, and the UK National Institute of Clinical Excellence (NICE) guideline. We recommend BT as a potential therapeutic intervention for severe uncontrolled asthma, provided that it is performed by an experienced pulmonologist at an accredited centre and done within the broader context of appropriate management of the disease by doctors experienced in treating difficult-to-control asthma.
    Original languageEnglish
    JournalSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
    Volume105
    Issue number10
    DOIs
    Publication statusPublished - Oct 2015

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