Individualised exercise improves endothelial function in patients with rheumatoid arthritis

George S. Metsios, Antonios Stavropoulos-Kalinoglou, Jet J C S Veldhuijzen Van Zanten, Peter Nightingale, Aamer Sandoo, Theodoros Dimitroulas, George D. Kitas, Yiannis Koutedakis

    Research output: Contribution to journalArticlepeer-review


    Background: We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods: Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). Results: At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p
    Original languageEnglish
    Pages (from-to)748-751
    Number of pages3
    JournalAnnals of the rheumatic diseases
    Issue number4
    Publication statusPublished - 2014


    • Cardiovascular Disease
    • Inflammation
    • Rehabilitation
    • Rheumatoid Arthritis


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