TY - JOUR
T1 - Individualised exercise improves endothelial function in patients with rheumatoid arthritis
AU - Metsios, George S.
AU - Stavropoulos-Kalinoglou, Antonios
AU - Van Zanten, Jet J C S Veldhuijzen
AU - Nightingale, Peter
AU - Sandoo, Aamer
AU - Dimitroulas, Theodoros
AU - Kitas, George D.
AU - Koutedakis, Yiannis
PY - 2014
Y1 - 2014
N2 - Background: We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods: Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). Results: At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p
AB - Background: We investigated the effects of individualised combined resistance and aerobic exercise on microvascular and macrovascular function in rheumatoid arthritis (RA) patients. Methods: Forty age-matched, gender-matched and body mass index (BMI)-matched patients were allocated to either an exercise group, receiving a 6 months tailored aerobic and resistance exercise intervention, or controls receiving only information about the benefits of exercise. Participants were assessed for microvascular (acetylcholine (Ach) and sodium nitroprusside (SNP)) and macrovascular (flow-mediated dilatation (FMD) and glyceryl trinitrate (GTN)) endothelial function, maximal oxygen uptake, disease activity and severity (C-reactive protein (CRP), disease activity score 28 and health assessment questionnaire). Data were collected at baseline, 3 months and at the end of the intervention (6 months). Results: At baseline, demographic, anthropometric, disease-related characteristics and endothelial function parameters were similar between the exercise and control groups (p>0.05). Repeated measures analysis of variance revealed a significant improvement in endothelial function parameters at 3 (GTN: p
KW - Cardiovascular Disease
KW - Inflammation
KW - Rehabilitation
KW - Rheumatoid Arthritis
U2 - 10.1136/annrheumdis-2013-203291
DO - 10.1136/annrheumdis-2013-203291
M3 - Article
C2 - 23904472
SN - 0003-4967
VL - 73
SP - 748
EP - 751
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 4
ER -