@article{4683f46aacba4617a07db483e451af2f,
title = "Indole-ynones as Privileged Substrates for Radical Dearomatizing Spirocyclization Cascades",
abstract = "Indole-ynones have been established as general substrates for radical dearomatizing spirocyclization cascade reactions. Five distinct and varied synthetic protocols have been developed─cyanomethylation, sulfonylation, trifluoromethylation, stannylation and borylation─using a variety of radical generation modes, ranging from photoredox catalysis to traditional AIBN methods. The simple and easily prepared indole-ynones can be used to rapidly generate diverse, densely functionalized spirocycles and have the potential to become routinely used to explore radical reactivity. Experimental and computational investigations support the proposed radical cascade mechanism and suggest that other new methods are now primed for development.",
author = "Nantachai Inprung and Ho, {Hon Eong} and Rossi-Ashton, {James A.} and Epton, {Ryan G.} and Whitwood, {Adrian C.} and Lynam, {Jason M.} and Taylor, {Richard J. K.} and James, {Michael J.} and Unsworth, {William P.}",
note = "Funding Information: The authors would like to thank the Development and Promotion of Science and Technology Talents Project (DPST), Royal Thai Government. (N.I. EP/N035119/1), the University of York, and the Leverhulme Trust (for an Early Career Fellowship, ECF-2019-135, M.J.J.) for financial support. We are also grateful to the University of York for the provision of an Eleanor Dodson Fellowship (to W.P.U.). Publisher Copyright: {\textcopyright} 2022 American Chemical Society",
year = "2022",
month = jan,
day = "21",
doi = "10.1021/acs.orglett.1c04098",
language = "English",
volume = "24",
pages = "668--674",
journal = "Organic Letters",
issn = "1523-7052",
publisher = "American Chemical Society",
number = "2",
}