As global life expectancy continues to rise we are challenged with maintaining health into old age. One strategy is to target the chronic low level inflammation associated with aging, termed ‘inflammaging’. This is characterized by increased levels of circulating pro-inflammatory cytokines and a shift toward cellular senescence; changes that are believed to drive many age-associated conditions including dementia, arthritis and type-2 diabetes. As with other organs the skin undergoes functional decline during aging, becoming more fragile and susceptible to infection; however, the contribution of inflammaging is not well understood. This review article describes the evidence for inflammaging in the skin, its relationship with senescence, and how this relates to declining skin structure and function.
|Journal||The Journal of Investigative Dermatology|
|Publication status||Accepted/In press - 2 Nov 2020|