Inflammatory Fabry cardiomyopathy demonstrated using simultaneous hybridised 18F-fluorodeoxyglucose positron emission tomography, cardiovascular magnetic resonance imaging

Christopher Orsborne; Jose M. Anton-Rodrigez; Neal Sherratt; Amy Watkins; Maelene Lohezic; David Clark; William Lloyd; Josephine Naish; Peter Woolfson; Anna Reid; Matthias Schmitt; Sivakumar Muthu; Parthiban Arumugam; Ana Jovanovic; Christopher Miller

Inflammatory Fabry cardiomyopathy demonstrated using simultaneous hybridised 18F-fluorodeoxyglucose positron emission tomography, cardiovascular magnetic resonance imaging

Christopher Orsborne, Jose M. Anton-Rodrigez, Neal Sherratt, Amy Watkins, Maelene Lohezic, David Clark, William Lloyd, Josephine Naish, Peter Woolfson, Anna Reid, Matthias Schmitt, Sivakumar Muthu, Parthiban Arumugam, Ana Jovanovic, Christopher Miller

Manchester University NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

Abstract

Using hybridised 18FDG-PET-CMR, we identify active myocardial inflammation, and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that LGE represents, at least in part, active myocardial inflammation, and identify an early inflammatory phenotype which may represent a therapeutic window before irreversible tissue injury and adaptation occurs.

Original language	English
Journal	JACC: Case Reports
Publication status	Accepted/In press - 7 Apr 2023

Keywords

Fabry disease
cardiovascular magnetic resonance
18fluorodeoxyglucose positron emission tomography
myocardial inflammation
myocardial fibrosis

Embargoed Document

Manuscript
Accepted author manuscript, 23.1 MB
Embargo ends: 1/01/33

Cite this

Orsborne, C., Anton-Rodrigez, J. M., Sherratt, N., Watkins, A., Lohezic, M., Clark, D., Lloyd, W., Naish, J., Woolfson, P., Reid, A., Schmitt, M., Muthu, S., Arumugam, P., Jovanovic, A., & Miller, C. (Accepted/In press). Inflammatory Fabry cardiomyopathy demonstrated using simultaneous hybridised 18F-fluorodeoxyglucose positron emission tomography, cardiovascular magnetic resonance imaging. JACC: Case Reports.

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title = "Inflammatory Fabry cardiomyopathy demonstrated using simultaneous hybridised 18F-fluorodeoxyglucose positron emission tomography, cardiovascular magnetic resonance imaging",

abstract = "Using hybridised 18FDG-PET-CMR, we identify active myocardial inflammation, and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that LGE represents, at least in part, active myocardial inflammation, and identify an early inflammatory phenotype which may represent a therapeutic window before irreversible tissue injury and adaptation occurs.",

keywords = "Fabry disease, cardiovascular magnetic resonance, 18fluorodeoxyglucose positron emission tomography, myocardial inflammation, myocardial fibrosis",

author = "Christopher Orsborne and Anton-Rodrigez, {Jose M.} and Neal Sherratt and Amy Watkins and Maelene Lohezic and David Clark and William Lloyd and Josephine Naish and Peter Woolfson and Anna Reid and Matthias Schmitt and Sivakumar Muthu and Parthiban Arumugam and Ana Jovanovic and Christopher Miller",

year = "2023",

month = apr,

day = "7",

language = "English",

journal = "JACC: Case Reports",

publisher = "American College of Cardiology",

}

Orsborne, C, Anton-Rodrigez, JM, Sherratt, N, Watkins, A, Lohezic, M, Clark, D, Lloyd, W, Naish, J, Woolfson, P, Reid, A, Schmitt, M, Muthu, S, Arumugam, P, Jovanovic, A & Miller, C 2023, 'Inflammatory Fabry cardiomyopathy demonstrated using simultaneous hybridised 18F-fluorodeoxyglucose positron emission tomography, cardiovascular magnetic resonance imaging', JACC: Case Reports.

TY - JOUR

T1 - Inflammatory Fabry cardiomyopathy demonstrated using simultaneous hybridised 18F-fluorodeoxyglucose positron emission tomography, cardiovascular magnetic resonance imaging

AU - Orsborne, Christopher

AU - Anton-Rodrigez, Jose M.

AU - Sherratt, Neal

AU - Watkins, Amy

AU - Lohezic, Maelene

AU - Clark, David

AU - Lloyd, William

AU - Naish, Josephine

AU - Woolfson, Peter

AU - Reid, Anna

AU - Schmitt, Matthias

AU - Muthu, Sivakumar

AU - Arumugam, Parthiban

AU - Jovanovic, Ana

AU - Miller, Christopher

PY - 2023/4/7

Y1 - 2023/4/7

N2 - Using hybridised 18FDG-PET-CMR, we identify active myocardial inflammation, and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that LGE represents, at least in part, active myocardial inflammation, and identify an early inflammatory phenotype which may represent a therapeutic window before irreversible tissue injury and adaptation occurs.

AB - Using hybridised 18FDG-PET-CMR, we identify active myocardial inflammation, and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that LGE represents, at least in part, active myocardial inflammation, and identify an early inflammatory phenotype which may represent a therapeutic window before irreversible tissue injury and adaptation occurs.

KW - Fabry disease

KW - cardiovascular magnetic resonance

KW - 18fluorodeoxyglucose positron emission tomography

KW - myocardial inflammation

KW - myocardial fibrosis

M3 - Article

JO - JACC: Case Reports

JF - JACC: Case Reports

ER -

Inflammatory Fabry cardiomyopathy demonstrated using simultaneous hybridised 18F-fluorodeoxyglucose positron emission tomography, cardiovascular magnetic resonance imaging

Abstract

Keywords

Embargoed Document

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