Inflammatory Fabry Cardiomyopathy Demonstrated Using Simultaneous [18F]-FDG PET-CMR

Christopher Orsborne, Jose M. Anton-Rodrigez, Neal Sherratt, Amy Watkins, Maelene Lohezic, David Clark, William Lloyd, Josephine H. Naish, Peter Woolfson, Anna B. Reid, Matthias Schmitt, Sivakumar Muthu, Parthiban Arumugam, Ana Jovanovic, Christopher A. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Using hybridized [18F]-fluorodeoxyglucose positron emission tomography with cardiac magnetic resonance, we identify active myocardial inflammation and demonstrate its relationship with late gadolinium enhancement, in Fabry disease. We demonstrate that late gadolinium enhancement represents, at least in part, active myocardial inflammation and identify an early inflammatory phenotype that may represent a therapeutic window before irreversible tissue injury and adaptation occur. (Level of Difficulty: Intermediate.)

Original languageEnglish
Article number101863
JournalJACC: Case Reports
Volume15
Early online date6 May 2023
DOIs
Publication statusPublished - 7 Jun 2023

Keywords

  • cardiovascular magnetic resonance
  • Fabry disease
  • myocardial fibrosis
  • myocardial inflammation
  • [F]-fluorodeoxyglucose positron emission tomography

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