Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?

Simon T Peake; David Bernardo; Elizabeth R Mann; Hafid O Al-Hassi; Stella C Knight; Ailsa L Hart

doi:10.1016/j.crohns.2013.01.001

Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?

Simon T Peake, David Bernardo, Elizabeth R Mann, Hafid O Al-Hassi, Stella C Knight, Ailsa L Hart

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	765-7
Number of pages	3
Journal	Journal of Crohn's and Colitis
Volume	7
Issue number	9
DOIs	https://doi.org/10.1016/j.crohns.2013.01.001
Publication status	Published - Oct 2013

Keywords

Antibodies, Monoclonal/pharmacology
B7 Antigens/metabolism
Cells, Cultured
Gastrointestinal Agents/pharmacology
Humans
Inflammation/chemically induced
Infliximab
Receptors, CCR4/metabolism
Receptors, CCR7/metabolism
Receptors, Lymphocyte Homing/metabolism
T-Lymphocytes/drug effects
Tumor Necrosis Factor-alpha/antagonists & inhibitors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.crohns.2013.01.001

Cite this

@article{02d197ba13724efd837db0131c34a0e0,

title = "Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?",

keywords = "Antibodies, Monoclonal/pharmacology, B7 Antigens/metabolism, Cells, Cultured, Gastrointestinal Agents/pharmacology, Humans, Inflammation/chemically induced, Infliximab, Receptors, CCR4/metabolism, Receptors, CCR7/metabolism, Receptors, Lymphocyte Homing/metabolism, T-Lymphocytes/drug effects, Tumor Necrosis Factor-alpha/antagonists & inhibitors",

author = "Peake, {Simon T} and David Bernardo and Mann, {Elizabeth R} and Al-Hassi, {Hafid O} and Knight, {Stella C} and Hart, {Ailsa L}",

year = "2013",

month = oct,

doi = "10.1016/j.crohns.2013.01.001",

language = "English",

volume = "7",

pages = "765--7",

journal = "Journal of Crohn's and Colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro

T2 - a novel mechanism for paradoxical inflammation?

AU - Peake, Simon T

AU - Bernardo, David

AU - Mann, Elizabeth R

AU - Al-Hassi, Hafid O

AU - Knight, Stella C

AU - Hart, Ailsa L

PY - 2013/10

Y1 - 2013/10

KW - Antibodies, Monoclonal/pharmacology

KW - B7 Antigens/metabolism

KW - Cells, Cultured

KW - Gastrointestinal Agents/pharmacology

KW - Humans

KW - Inflammation/chemically induced

KW - Infliximab

KW - Receptors, CCR4/metabolism

KW - Receptors, CCR7/metabolism

KW - Receptors, Lymphocyte Homing/metabolism

KW - T-Lymphocytes/drug effects

KW - Tumor Necrosis Factor-alpha/antagonists & inhibitors

U2 - 10.1016/j.crohns.2013.01.001

DO - 10.1016/j.crohns.2013.01.001

M3 - Article

C2 - 23352576

SN - 1873-9946

VL - 7

SP - 765

EP - 767

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

IS - 9

ER -