Influence of access site selection on PCI-related adverse events in patients with STEMI: Meta-analysis of randomised controlled trials

Mamas Mamas, Mamas A. Mamas, Karim Ratib, Helen Routledge, Farzin Fath-Ordoubadi, Ludwig Neyses, Yves Louvard, Douglas G. Fraser, Jim Nolan

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: A meta-analysis of all randomised controlled studies that compare outcomes of transradial versus the transfemoral route to better define best practice in patients with ST elevation myocardial infarction (STEMI). Design: A Medline and Embase search was conducted using the search terms 'transradial,' 'radial', 'STEMI', 'myocardial' and 'infarction'. Setting: Randomised controlled studies that compare outcomes of transradial versus the transfemoral route. Patients: A total of nine studies were identified that consisted of 2977 patients with STEMI. Interventions Studies that compare outcomes of transradial versus the transfemoral route. Main outcome measures: The primary clinical outcomes of interest were (1) mortality; (2) major adverse cardiac events (MACE); (3) major bleeding and (4) access site complications. Results: Transradial PCI was associated with a reduction in mortality (OR 0.53, 95% CI 0.33 to 0.84; p=0.008), MACE (OR 0.62, 95% CI 0.43 to 0.90; p=0.012), major bleeding events (OR 0.63, 95% CI 0.35-1.12; p=0.12) and access site complications (OR 0.30, 95% CI 0.19 to 0.48; p
    Original languageEnglish
    Pages (from-to)303-311
    Number of pages8
    JournalHeart
    Volume98
    Issue number4
    DOIs
    Publication statusPublished - Feb 2012

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