Abstract
While many studies have examined the associations between APOE genotype and mortality, findings have often
been conflicting and it remains unclear whether APOE genotype affects longevity. Using selected individuals from the
Manchester arm of the Brains for Dementia Research programme and University of Manchester Longitudinal Study of
Cognition in Normal Healthy Old Age, we investigated relationships between APOE genotype and age at death in both
cognitively normal and cognitively impaired individuals. Results indicated that carrying the APOE 4 allele led to a reduced
chance in an individual reaching 80+ years and remaining cognitively healthy. Conversely, APOE 2 carriers tended to live
longer and remain cognitively normal. These findings add to the evidence that APOE genotype influences longevity, especially
in cognitively impaired individuals who carry the APOE 4 allele.
been conflicting and it remains unclear whether APOE genotype affects longevity. Using selected individuals from the
Manchester arm of the Brains for Dementia Research programme and University of Manchester Longitudinal Study of
Cognition in Normal Healthy Old Age, we investigated relationships between APOE genotype and age at death in both
cognitively normal and cognitively impaired individuals. Results indicated that carrying the APOE 4 allele led to a reduced
chance in an individual reaching 80+ years and remaining cognitively healthy. Conversely, APOE 2 carriers tended to live
longer and remain cognitively normal. These findings add to the evidence that APOE genotype influences longevity, especially
in cognitively impaired individuals who carry the APOE 4 allele.
| Original language | English |
|---|---|
| Pages (from-to) | 281-286 |
| Number of pages | 6 |
| Journal | Journal of Alzheimer's Disease Reports |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 23 Jul 2020 |