Influence of lecithin on some physical chemical properties of poloxamer gels: Rheological, microscopic and in vitro permeation studies

M. Vitória L B Bentley, Juliana M. Marchetti, Nágila Ricardo, Ziad Ali-Abi, John H. Collett

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Thermoreversible gels may be used in delivery systems which require a sol-gel transition at body temperature. The influence of the addition of lecithin, a permeation enhancer, on the rheological and in vitro permeation properties of poloxamer 407 gels was investigated. Light microscopy and rheological parameters were used to characterize the microscopic structure of the formulations which showed non Newtonian behaviour, pseudoplastic flow with a yield value. Increased concentrations of lecithin increased the thixotropy, yield value, apparent viscosity, and the gelation temperature of the gels. Light microscopy showed the formation of micellar structures by the addition of lecithin, which may account for changes in rheological properties. In vitro permeation of a model drug, triamcinolone acetonide, was decreased when the lecithin concentration was increased. The presence of lecithin in the poloxamer gel improved the characteristics for topical drug delivery.
    Original languageEnglish
    Pages (from-to)49-55
    Number of pages6
    JournalInternational Journal of Pharmaceutics
    Volume193
    Issue number1
    DOIs
    Publication statusPublished - 20 Dec 1999

    Keywords

    • Lecithin
    • Penetration enhancer
    • Poloxamer 407 gels
    • Rheological study

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