Abstract
Energy balance and brown adipose tissue (BAT) metabolism were studied in rats maintained on stock or 'cafeteria' diet, and injected with either saline or triiodothyronine (T3, 10 μg/100 g b.wt./d) for 14 d. Cafeteria-fed rats showed large increases in metabolizable energy intake, energy expenditure and BAT mass, Na+, K+-ATPase activity and mitochondrial GDP binding. In stock fed rats, T3 also stimulated energy intake, metabolic rate and BAT and mass and Na+, K+-ATPase activity, but did not affect GDP binding. Hyperthyroidism potentiated the effects of cafeteria feeding on energy expenditure and BAT mass, but BAT Na+,K+-ATPase activity was only slightly higher than that of the euthyroid cafeteria rats, and GDP binding was similar for both groups. These results confirm the involvement of BAT in diet-induced thermogenesis and show that this is potentiated by hyperthyroidism. The data also suggest that thyroid thermogenesis may result, at least partly, from stimulation of BAT.
| Original language | English |
|---|---|
| Pages (from-to) | 394-398 |
| Number of pages | 4 |
| Journal | Hormone and Metabolic Research |
| Volume | 15 |
| Issue number | 8 |
| Publication status | Published - 1983 |