Influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus)

Fiona I J Crawford; Cassandra L. Hodgkinson; Elena Ivanova; Larisa B. Logunova; Gary J. Evans; Stephan Steinlechner; Andrew S I Loudon

doi:10.1152/physiolgenomics.00131.2007

Influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus)

Fiona I J Crawford, Cassandra L. Hodgkinson, Elena Ivanova, Larisa B. Logunova, Gary J. Evans, Stephan Steinlechner, Andrew S I Loudon

Research output: Contribution to journal › Article › peer-review

Abstract

The Siberian hamster exhibits the key winter adaptive strategy of daily torpor, during which metabolism and heart rate are slowed for a few hours and body temperature declines by up to 20°C, allowing substantial energetic savings. Previous studies of hibernators in which temperature drops by >30°C for many days to weeks have revealed decreased transcription and translation during hypometabolism and identified several key physiological pathways involved. Here we used a cDNA microarray to define cardiac transcript changes over the course of a daily torpor bout and return to normothermia, and we show that, in common with hibernators, a relatively small proportion of the transcriptome (

Original language	English
Pages (from-to)	521-530
Number of pages	9
Journal	Physiological Genomics
Volume	31
Issue number	3
DOIs	https://doi.org/10.1152/physiolgenomics.00131.2007
Publication status	Published - 14 Nov 2007

Keywords

Djungarian hamster
Hibernation
Hypometabolism
Microarray
Ubiquitylation

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10.1152/physiolgenomics.00131.2007

http://physiolgenomics.physiology.org/cgi/reprint/31/3/521

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title = "Influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus)",

abstract = "The Siberian hamster exhibits the key winter adaptive strategy of daily torpor, during which metabolism and heart rate are slowed for a few hours and body temperature declines by up to 20°C, allowing substantial energetic savings. Previous studies of hibernators in which temperature drops by >30°C for many days to weeks have revealed decreased transcription and translation during hypometabolism and identified several key physiological pathways involved. Here we used a cDNA microarray to define cardiac transcript changes over the course of a daily torpor bout and return to normothermia, and we show that, in common with hibernators, a relatively small proportion of the transcriptome (",

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AU - Ivanova, Elena

AU - Logunova, Larisa B.

AU - Evans, Gary J.

AU - Steinlechner, Stephan

AU - Loudon, Andrew S I

PY - 2007/11/14

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KW - Djungarian hamster

KW - Hibernation

KW - Hypometabolism

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KW - Ubiquitylation

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Influence of torpor on cardiac expression of genes involved in the circadian clock and protein turnover in the Siberian hamster (Phodopus sungorus)

Abstract

Keywords

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