Inhaled corticosteroids and decline of lung function in community residents with asthma

P. Lange; H. Scharling; C. S. Ulrik; J. Vestbo

doi:10.1136/thx.2004.037978

Inhaled corticosteroids and decline of lung function in community residents with asthma

P. Lange, H. Scharling, C. S. Ulrik, J. Vestbo

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Inhaled corticosteroids (ICS) constitute the cornerstone of treatment for asthma. Many studies have reported beneficial short term effects of these drugs, but there are few data on the long term effects of ICS on the decline in forced expiratory volume in 1 second (FEV1). This study was undertaken to determine whether adults with asthma treated with ICS have a less pronounced decline in FEV1 than those not treated with ICS. Methods: Two hundred and thirty four asthmatic individuals from a longitudinal epidemiological study of the general population of Copenhagen, Denmark were divided into two groups; 44 were treated with ICS and 190 were not treated with ICS. The annual decline in FEV1 was measured over a 10 year follow up period. Results: The decline in FEV1 in the 44 patients receiving ICS was 25 ml/year compared with 51 ml/year in the 190 patients not receiving this treatment (p

Original language	English
Pages (from-to)	100-104
Number of pages	4
Journal	Thorax
Volume	61
Issue number	2
DOIs	https://doi.org/10.1136/thx.2004.037978
Publication status	Published - Feb 2006

Keywords

Administration, Inhalation
administration & dosage: Adrenal Cortex Hormones
drug therapy: Asthma
Disease Progression
Female
drug effects: Forced Expiratory Volume
Humans
Male
Middle Aged
Research Support, Non-U.S. Gov't
physiology: Vital Capacity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/thx.2004.037978

Cite this

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title = "Inhaled corticosteroids and decline of lung function in community residents with asthma",

abstract = "Background: Inhaled corticosteroids (ICS) constitute the cornerstone of treatment for asthma. Many studies have reported beneficial short term effects of these drugs, but there are few data on the long term effects of ICS on the decline in forced expiratory volume in 1 second (FEV1). This study was undertaken to determine whether adults with asthma treated with ICS have a less pronounced decline in FEV1 than those not treated with ICS. Methods: Two hundred and thirty four asthmatic individuals from a longitudinal epidemiological study of the general population of Copenhagen, Denmark were divided into two groups; 44 were treated with ICS and 190 were not treated with ICS. The annual decline in FEV1 was measured over a 10 year follow up period. Results: The decline in FEV1 in the 44 patients receiving ICS was 25 ml/year compared with 51 ml/year in the 190 patients not receiving this treatment (p",

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author = "P. Lange and H. Scharling and Ulrik, {C. S.} and J. Vestbo",

year = "2006",

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doi = "10.1136/thx.2004.037978",

language = "English",

volume = "61",

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journal = "Thorax",

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T1 - Inhaled corticosteroids and decline of lung function in community residents with asthma

AU - Lange, P.

AU - Scharling, H.

AU - Ulrik, C. S.

AU - Vestbo, J.

PY - 2006/2

Y1 - 2006/2

N2 - Background: Inhaled corticosteroids (ICS) constitute the cornerstone of treatment for asthma. Many studies have reported beneficial short term effects of these drugs, but there are few data on the long term effects of ICS on the decline in forced expiratory volume in 1 second (FEV1). This study was undertaken to determine whether adults with asthma treated with ICS have a less pronounced decline in FEV1 than those not treated with ICS. Methods: Two hundred and thirty four asthmatic individuals from a longitudinal epidemiological study of the general population of Copenhagen, Denmark were divided into two groups; 44 were treated with ICS and 190 were not treated with ICS. The annual decline in FEV1 was measured over a 10 year follow up period. Results: The decline in FEV1 in the 44 patients receiving ICS was 25 ml/year compared with 51 ml/year in the 190 patients not receiving this treatment (p

AB - Background: Inhaled corticosteroids (ICS) constitute the cornerstone of treatment for asthma. Many studies have reported beneficial short term effects of these drugs, but there are few data on the long term effects of ICS on the decline in forced expiratory volume in 1 second (FEV1). This study was undertaken to determine whether adults with asthma treated with ICS have a less pronounced decline in FEV1 than those not treated with ICS. Methods: Two hundred and thirty four asthmatic individuals from a longitudinal epidemiological study of the general population of Copenhagen, Denmark were divided into two groups; 44 were treated with ICS and 190 were not treated with ICS. The annual decline in FEV1 was measured over a 10 year follow up period. Results: The decline in FEV1 in the 44 patients receiving ICS was 25 ml/year compared with 51 ml/year in the 190 patients not receiving this treatment (p

KW - Administration, Inhalation

KW - administration & dosage: Adrenal Cortex Hormones

KW - drug therapy: Asthma

KW - Disease Progression

KW - Female

KW - drug effects: Forced Expiratory Volume

KW - Humans

KW - Male

KW - Middle Aged

KW - Research Support, Non-U.S. Gov't

KW - physiology: Vital Capacity

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DO - 10.1136/thx.2004.037978

M3 - Article

SN - 0040-6376

VL - 61

SP - 100

EP - 104

JO - Thorax

JF - Thorax

IS - 2

ER -

Inhaled corticosteroids and decline of lung function in community residents with asthma

Abstract

Keywords

UN SDGs

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