Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: Comparison with other steroid metabolizing enzymes

D. Deluca; A. Krazeisen; R. Breitling; C. Prehn; G. Möller; J. Adamski

doi:10.1016/j.jsbmb.2004.12.035

Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: Comparison with other steroid metabolizing enzymes

D. Deluca, A. Krazeisen, R. Breitling, C. Prehn, G. Möller, J. Adamski

Research output: Contribution to journal › Article › peer-review

Abstract

Effects of phytoestrogens on human health have been reported for decades. These include not only beneficial action in cancer prevention but also endocrine disruption in males. Since then many molecular mechanisms underlying these effects have been identified. Targets of phytoestrogens comprise steroid receptors, steroid metabolising enzymes, elements of signal transduction and apoptosis pathways, and even the DNA processing machinery. Understanding the specific versus pleiotropic effects of selected phytoestrogens will be crucial for their biomedical application. This review will concentrate on the influence of phytoestrogens on 17beta-hydroxysteroid dehydrogenases from a comparative perspective with other steroid metabolizing enzymes. © 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	285-292
Number of pages	7
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	93
Issue number	2-5
DOIs	https://doi.org/10.1016/j.jsbmb.2004.12.035
Publication status	Published - Feb 2005

Keywords

17beta-Hydroxysteroid dehydrogenase
Flavonoids
Phytoestrogens

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jsbmb.2004.12.035

Cite this

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title = "Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: Comparison with other steroid metabolizing enzymes",

abstract = "Effects of phytoestrogens on human health have been reported for decades. These include not only beneficial action in cancer prevention but also endocrine disruption in males. Since then many molecular mechanisms underlying these effects have been identified. Targets of phytoestrogens comprise steroid receptors, steroid metabolising enzymes, elements of signal transduction and apoptosis pathways, and even the DNA processing machinery. Understanding the specific versus pleiotropic effects of selected phytoestrogens will be crucial for their biomedical application. This review will concentrate on the influence of phytoestrogens on 17beta-hydroxysteroid dehydrogenases from a comparative perspective with other steroid metabolizing enzymes. {\textcopyright} 2004 Elsevier Ltd. All rights reserved.",

keywords = "17beta-Hydroxysteroid dehydrogenase, Flavonoids, Phytoestrogens",

author = "D. Deluca and A. Krazeisen and R. Breitling and C. Prehn and G. M{\"o}ller and J. Adamski",

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T1 - Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: Comparison with other steroid metabolizing enzymes

AU - Deluca, D.

AU - Krazeisen, A.

AU - Breitling, R.

AU - Prehn, C.

AU - Möller, G.

AU - Adamski, J.

PY - 2005/2

Y1 - 2005/2

N2 - Effects of phytoestrogens on human health have been reported for decades. These include not only beneficial action in cancer prevention but also endocrine disruption in males. Since then many molecular mechanisms underlying these effects have been identified. Targets of phytoestrogens comprise steroid receptors, steroid metabolising enzymes, elements of signal transduction and apoptosis pathways, and even the DNA processing machinery. Understanding the specific versus pleiotropic effects of selected phytoestrogens will be crucial for their biomedical application. This review will concentrate on the influence of phytoestrogens on 17beta-hydroxysteroid dehydrogenases from a comparative perspective with other steroid metabolizing enzymes. © 2004 Elsevier Ltd. All rights reserved.

AB - Effects of phytoestrogens on human health have been reported for decades. These include not only beneficial action in cancer prevention but also endocrine disruption in males. Since then many molecular mechanisms underlying these effects have been identified. Targets of phytoestrogens comprise steroid receptors, steroid metabolising enzymes, elements of signal transduction and apoptosis pathways, and even the DNA processing machinery. Understanding the specific versus pleiotropic effects of selected phytoestrogens will be crucial for their biomedical application. This review will concentrate on the influence of phytoestrogens on 17beta-hydroxysteroid dehydrogenases from a comparative perspective with other steroid metabolizing enzymes. © 2004 Elsevier Ltd. All rights reserved.

KW - 17beta-Hydroxysteroid dehydrogenase

KW - Flavonoids

KW - Phytoestrogens

U2 - 10.1016/j.jsbmb.2004.12.035

DO - 10.1016/j.jsbmb.2004.12.035

M3 - Article

SN - 0960-0760

VL - 93

SP - 285

EP - 292

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

IS - 2-5

ER -

Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: Comparison with other steroid metabolizing enzymes

Abstract

Keywords

UN SDGs

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