Inpatient drug utilization in Europe: nationwide data sources and a review of publications on a selected group of medicines (PROTECT project).

Tjeerd Van Staa; Robert Reynolds; Olaf Klungel; Y Alvarez; J Slattery; X Kurz; G Candoere; J Durand; S Blackburn; M Rottenkolber; J Hasford; A Stueven; F J de Abajo Iglesias; E Martin Merino; M Gil; C Huerta; D Montero; R González; L A Garcia-Rodriguez; A Ruigomez; P C Souverein; L van Dijk; A Afonso; M De Groot; H Gardarsdottir; R Van den Ham; S Belitser; A de Boer; R Groenwold; A W Hoes; K C B Roes; A Sanni; J Uddin; D De Bakker; W Pestman; V Abbing-Krahagopian; F De Vries; T Egberts; H G M Leufkens; O H Klungel; I Teixidor; M de Bruin; J Parkinson; J Campbell; A Gallagher; T van Staa; E Ng; K Bhaskaran; I Douglas; L Smeeth; K Wing; M Ranopa; P Helboe; J Lyngvig; A M Clemensen; T S Engraff; U Hesse; J Poulsen; P F Rønn; J Logie; J Pimenta; K Davis; E J Swain; L Abenhaim; R F Reynolds; N Gatto; A Bate; J Richards; M Feudjo-Tepie; G F Downey; R Brauer; J Amelio; A Roddam; O Demol; S Johansson; P Primatesta; R Schlienger; J Fortuny; E Rivero; E Plana Hortoneda; I Tatt; J Hannon; J Robinson; S Vesanen; M Schuerch; J-R Laporte; L Ibáñez; M Sabaté; E Ballarín; M Pérez; P Ferrer; S Schmiedl; L Bensouda-Grimaldi; B Rahaelle; A Micaleff

doi:10.1111/bcpt.12358

Inpatient drug utilization in Europe: nationwide data sources and a review of publications on a selected group of medicines (PROTECT project).

Tjeerd Van Staa, Robert Reynolds, Olaf Klungel, Y Alvarez (Collaborator), J Slattery (Collaborator), X Kurz (Collaborator), G Candoere (Collaborator), J Durand (Collaborator), S Blackburn (Collaborator), M Rottenkolber (Collaborator), J Hasford (Collaborator), A Stueven (Collaborator), F J de Abajo Iglesias (Collaborator), E Martin Merino (Collaborator), M Gil (Collaborator), C Huerta (Collaborator), D Montero (Collaborator), R González (Collaborator), L A Garcia-Rodriguez (Collaborator), A Ruigomez (Collaborator)P C Souverein (Collaborator), L van Dijk (Collaborator), A Afonso (Collaborator), M De Groot (Collaborator), H Gardarsdottir (Collaborator), R Van den Ham (Collaborator), S Belitser (Collaborator), A de Boer (Collaborator), R Groenwold (Collaborator), A W Hoes (Collaborator), K C B Roes (Collaborator), A Sanni (Collaborator), J Uddin (Collaborator), D De Bakker (Collaborator), W Pestman (Collaborator), V Abbing-Krahagopian (Collaborator), F De Vries (Collaborator), T Egberts (Collaborator), H G M Leufkens (Collaborator), O H Klungel (Collaborator), I Teixidor (Collaborator), M de Bruin (Collaborator), J Parkinson (Collaborator), J Campbell (Collaborator), A Gallagher (Collaborator), T van Staa (Collaborator), E Ng (Collaborator), K Bhaskaran (Collaborator), I Douglas (Collaborator), L Smeeth (Collaborator), K Wing (Collaborator), M Ranopa (Collaborator), P Helboe (Collaborator), J Lyngvig (Collaborator), A M Clemensen (Collaborator), T S Engraff (Collaborator), U Hesse (Collaborator), J Poulsen (Collaborator), P F Rønn (Collaborator), J Logie (Collaborator), J Pimenta (Collaborator), K Davis (Collaborator), E J Swain (Collaborator), L Abenhaim (Collaborator), R F Reynolds (Collaborator), N Gatto (Collaborator), A Bate (Collaborator), J Richards (Collaborator), M Feudjo-Tepie (Collaborator), G F Downey (Collaborator), R Brauer (Collaborator), J Amelio (Collaborator), A Roddam (Collaborator), O Demol (Collaborator), S Johansson (Collaborator), P Primatesta (Collaborator), R Schlienger (Collaborator), J Fortuny (Collaborator), E Rivero (Collaborator), E Plana Hortoneda (Collaborator), I Tatt (Collaborator), J Hannon (Collaborator), J Robinson (Collaborator), S Vesanen (Collaborator), M Schuerch (Collaborator), J-R Laporte (Collaborator), L Ibáñez (Collaborator), M Sabaté (Collaborator), E Ballarín (Collaborator), M Pérez (Collaborator), P Ferrer (Collaborator), S Schmiedl (Collaborator), L Bensouda-Grimaldi (Collaborator), B Rahaelle (Collaborator), A Micaleff (Collaborator)

Research output: Contribution to journal › Article › peer-review

Abstract

Drug utilization (DU) studies in inpatient settings at a national level are rarely conducted. The main objective of this study was to review the general information on hospital medicine management in Europe and to report on the availability and characteristics of nationwide administrative drug consumption databases. A secondary objective was to perform a review of published studies on hospital DU of a group of selected drugs, focusing on methodological characteristics (ATC/DDD). General information on hospital drug management was retrieved from several websites, nationwide administrative drug consumption databases and reports published by governmental organizations. A PubMed search was conducted using keywords related to the selected group of drugs AND 'hospital drug utilization'. The data sources for hospital DU information varied widely and included 14 databases from 25 reviewed countries. Bulgaria, Croatia, Denmark, Estonia, Finland, France, Hungary, Iceland, Latvia, Norway and Sweden obtain information on inpatient DU at a national level from wholesalers/manufacturers. In Belgium, Italy and Portugal, drugs dispensed to patients in hospitals are registered at a national level. Data are freely available online only for Denmark and Iceland. From the PubMed search, of a total of 868 retrieved studies, only 13 studies used the ATC/DDD methodology. Although the number of DDD/100 bed-days was used in four studies, other units of measure were also used. The type of information provided for the inpatient sector allowed primarily for conducting DU research at an aggregated data level. The existence of national administrative structures to monitor hospital DU would contribute to promoting the rational use of medicines and improving the safety and quality of prescribing.

Original language	English
Journal	Basic & clinical pharmacology & toxicology
Volume	116
Issue number	3
DOIs	https://doi.org/10.1111/bcpt.12358
Publication status	Published - Mar 2015

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10.1111/bcpt.12358

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Van Staa, T., Reynolds, R., Klungel, O., Alvarez, Y., Slattery, J., Kurz, X., Candoere, G., Durand, J., Blackburn, S., Rottenkolber, M., Hasford, J., Stueven, A., de Abajo Iglesias, F. J., Martin Merino, E., Gil, M., Huerta, C., Montero, D., González, R., Garcia-Rodriguez, L. A., ... Micaleff, A. (2015). Inpatient drug utilization in Europe: nationwide data sources and a review of publications on a selected group of medicines (PROTECT project). Basic & clinical pharmacology & toxicology, 116(3). https://doi.org/10.1111/bcpt.12358

@article{16a65017853142f9851229de0573c690,

title = "Inpatient drug utilization in Europe: nationwide data sources and a review of publications on a selected group of medicines (PROTECT project).",

abstract = "Drug utilization (DU) studies in inpatient settings at a national level are rarely conducted. The main objective of this study was to review the general information on hospital medicine management in Europe and to report on the availability and characteristics of nationwide administrative drug consumption databases. A secondary objective was to perform a review of published studies on hospital DU of a group of selected drugs, focusing on methodological characteristics (ATC/DDD). General information on hospital drug management was retrieved from several websites, nationwide administrative drug consumption databases and reports published by governmental organizations. A PubMed search was conducted using keywords related to the selected group of drugs AND 'hospital drug utilization'. The data sources for hospital DU information varied widely and included 14 databases from 25 reviewed countries. Bulgaria, Croatia, Denmark, Estonia, Finland, France, Hungary, Iceland, Latvia, Norway and Sweden obtain information on inpatient DU at a national level from wholesalers/manufacturers. In Belgium, Italy and Portugal, drugs dispensed to patients in hospitals are registered at a national level. Data are freely available online only for Denmark and Iceland. From the PubMed search, of a total of 868 retrieved studies, only 13 studies used the ATC/DDD methodology. Although the number of DDD/100 bed-days was used in four studies, other units of measure were also used. The type of information provided for the inpatient sector allowed primarily for conducting DU research at an aggregated data level. The existence of national administrative structures to monitor hospital DU would contribute to promoting the rational use of medicines and improving the safety and quality of prescribing.",

author = "{Van Staa}, Tjeerd and Robert Reynolds and Olaf Klungel and Y Alvarez and J Slattery and X Kurz and G Candoere and J Durand and S Blackburn and M Rottenkolber and J Hasford and A Stueven and {de Abajo Iglesias}, {F J} and {Martin Merino}, E and M Gil and C Huerta and D Montero and R Gonz{\'a}lez and Garcia-Rodriguez, {L A} and A Ruigomez and Souverein, {P C} and {van Dijk}, L and A Afonso and {De Groot}, M and H Gardarsdottir and {Van den Ham}, R and S Belitser and {de Boer}, A and R Groenwold and Hoes, {A W} and Roes, {K C B} and A Sanni and J Uddin and {De Bakker}, D and W Pestman and V Abbing-Krahagopian and {De Vries}, F and T Egberts and Leufkens, {H G M} and Klungel, {O H} and I Teixidor and {de Bruin}, M and J Parkinson and J Campbell and A Gallagher and {van Staa}, T and E Ng and K Bhaskaran and I Douglas and L Smeeth and K Wing and M Ranopa and P Helboe and J Lyngvig and Clemensen, {A M} and Engraff, {T S} and U Hesse and J Poulsen and R{\o}nn, {P F} and J Logie and J Pimenta and K Davis and Swain, {E J} and L Abenhaim and Reynolds, {R F} and N Gatto and A Bate and J Richards and M Feudjo-Tepie and Downey, {G F} and R Brauer and J Amelio and A Roddam and O Demol and S Johansson and P Primatesta and R Schlienger and J Fortuny and E Rivero and {Plana Hortoneda}, E and I Tatt and J Hannon and J Robinson and S Vesanen and M Schuerch and J-R Laporte and L Ib{\'a}{\~n}ez and M Sabat{\'e} and E Ballar{\'i}n and M P{\'e}rez and P Ferrer and S Schmiedl and L Bensouda-Grimaldi and B Rahaelle and A Micaleff",

year = "2015",

month = mar,

doi = "10.1111/bcpt.12358",

language = "English",

volume = "116",

journal = "Basic & clinical pharmacology & toxicology",

issn = "1742-7843",

publisher = "John Wiley & Sons Ltd",

number = "3",

}

Van Staa, T, Reynolds, R, Klungel, O, Alvarez, Y, Slattery, J, Kurz, X, Candoere, G, Durand, J, Blackburn, S, Rottenkolber, M, Hasford, J, Stueven, A, de Abajo Iglesias, FJ, Martin Merino, E, Gil, M, Huerta, C, Montero, D, González, R, Garcia-Rodriguez, LA, Ruigomez, A, Souverein, PC, van Dijk, L, Afonso, A, De Groot, M, Gardarsdottir, H, Van den Ham, R, Belitser, S, de Boer, A, Groenwold, R, Hoes, AW, Roes, KCB, Sanni, A, Uddin, J, De Bakker, D, Pestman, W, Abbing-Krahagopian, V, De Vries, F, Egberts, T, Leufkens, HGM, Klungel, OH, Teixidor, I, de Bruin, M, Parkinson, J, Campbell, J, Gallagher, A, van Staa, T, Ng, E, Bhaskaran, K, Douglas, I, Smeeth, L, Wing, K, Ranopa, M, Helboe, P, Lyngvig, J, Clemensen, AM, Engraff, TS, Hesse, U, Poulsen, J, Rønn, PF, Logie, J, Pimenta, J, Davis, K, Swain, EJ, Abenhaim, L, Reynolds, RF, Gatto, N, Bate, A, Richards, J, Feudjo-Tepie, M, Downey, GF, Brauer, R, Amelio, J, Roddam, A, Demol, O, Johansson, S, Primatesta, P, Schlienger, R, Fortuny, J, Rivero, E, Plana Hortoneda, E, Tatt, I, Hannon, J, Robinson, J, Vesanen, S, Schuerch, M, Laporte, J-R, Ibáñez, L, Sabaté, M, Ballarín, E, Pérez, M, Ferrer, P, Schmiedl, S, Bensouda-Grimaldi, L, Rahaelle, B & Micaleff, A 2015, 'Inpatient drug utilization in Europe: nationwide data sources and a review of publications on a selected group of medicines (PROTECT project).', Basic & clinical pharmacology & toxicology, vol. 116, no. 3. https://doi.org/10.1111/bcpt.12358

TY - JOUR

T1 - Inpatient drug utilization in Europe: nationwide data sources and a review of publications on a selected group of medicines (PROTECT project).

AU - Van Staa, Tjeerd

AU - Reynolds, Robert

AU - Klungel, Olaf

A2 - Alvarez, Y

A2 - Slattery, J

A2 - Kurz, X

A2 - Candoere, G

A2 - Durand, J

A2 - Blackburn, S

A2 - Rottenkolber, M

A2 - Hasford, J

A2 - Stueven, A

A2 - de Abajo Iglesias, F J

A2 - Martin Merino, E

A2 - Gil, M

A2 - Huerta, C

A2 - Montero, D

A2 - González, R

A2 - Garcia-Rodriguez, L A

A2 - Ruigomez, A

A2 - Souverein, P C

A2 - van Dijk, L

A2 - Afonso, A

A2 - De Groot, M

A2 - Gardarsdottir, H

A2 - Van den Ham, R

A2 - Belitser, S

A2 - de Boer, A

A2 - Groenwold, R

A2 - Hoes, A W

A2 - Roes, K C B

A2 - Sanni, A

A2 - Uddin, J

A2 - De Bakker, D

A2 - Pestman, W

A2 - Abbing-Krahagopian, V

A2 - De Vries, F

A2 - Egberts, T

A2 - Leufkens, H G M

A2 - Klungel, O H

A2 - Teixidor, I

A2 - de Bruin, M

A2 - Parkinson, J

A2 - Campbell, J

A2 - Gallagher, A

A2 - van Staa, T

A2 - Ng, E

A2 - Bhaskaran, K

A2 - Douglas, I

A2 - Smeeth, L

A2 - Wing, K

A2 - Ranopa, M

A2 - Helboe, P

A2 - Lyngvig, J

A2 - Clemensen, A M

A2 - Engraff, T S

A2 - Hesse, U

A2 - Poulsen, J

A2 - Rønn, P F

A2 - Logie, J

A2 - Pimenta, J

A2 - Davis, K

A2 - Swain, E J

A2 - Abenhaim, L

A2 - Reynolds, R F

A2 - Gatto, N

A2 - Bate, A

A2 - Richards, J

A2 - Feudjo-Tepie, M

A2 - Downey, G F

A2 - Brauer, R

A2 - Amelio, J

A2 - Roddam, A

A2 - Demol, O

A2 - Johansson, S

A2 - Primatesta, P

A2 - Schlienger, R

A2 - Fortuny, J

A2 - Rivero, E

A2 - Plana Hortoneda, E

A2 - Tatt, I

A2 - Hannon, J

A2 - Robinson, J

A2 - Vesanen, S

A2 - Schuerch, M

A2 - Laporte, J-R

A2 - Ibáñez, L

A2 - Sabaté, M

A2 - Ballarín, E

A2 - Pérez, M

A2 - Ferrer, P

A2 - Schmiedl, S

A2 - Bensouda-Grimaldi, L

A2 - Rahaelle, B

A2 - Micaleff, A

PY - 2015/3

Y1 - 2015/3

N2 - Drug utilization (DU) studies in inpatient settings at a national level are rarely conducted. The main objective of this study was to review the general information on hospital medicine management in Europe and to report on the availability and characteristics of nationwide administrative drug consumption databases. A secondary objective was to perform a review of published studies on hospital DU of a group of selected drugs, focusing on methodological characteristics (ATC/DDD). General information on hospital drug management was retrieved from several websites, nationwide administrative drug consumption databases and reports published by governmental organizations. A PubMed search was conducted using keywords related to the selected group of drugs AND 'hospital drug utilization'. The data sources for hospital DU information varied widely and included 14 databases from 25 reviewed countries. Bulgaria, Croatia, Denmark, Estonia, Finland, France, Hungary, Iceland, Latvia, Norway and Sweden obtain information on inpatient DU at a national level from wholesalers/manufacturers. In Belgium, Italy and Portugal, drugs dispensed to patients in hospitals are registered at a national level. Data are freely available online only for Denmark and Iceland. From the PubMed search, of a total of 868 retrieved studies, only 13 studies used the ATC/DDD methodology. Although the number of DDD/100 bed-days was used in four studies, other units of measure were also used. The type of information provided for the inpatient sector allowed primarily for conducting DU research at an aggregated data level. The existence of national administrative structures to monitor hospital DU would contribute to promoting the rational use of medicines and improving the safety and quality of prescribing.

AB - Drug utilization (DU) studies in inpatient settings at a national level are rarely conducted. The main objective of this study was to review the general information on hospital medicine management in Europe and to report on the availability and characteristics of nationwide administrative drug consumption databases. A secondary objective was to perform a review of published studies on hospital DU of a group of selected drugs, focusing on methodological characteristics (ATC/DDD). General information on hospital drug management was retrieved from several websites, nationwide administrative drug consumption databases and reports published by governmental organizations. A PubMed search was conducted using keywords related to the selected group of drugs AND 'hospital drug utilization'. The data sources for hospital DU information varied widely and included 14 databases from 25 reviewed countries. Bulgaria, Croatia, Denmark, Estonia, Finland, France, Hungary, Iceland, Latvia, Norway and Sweden obtain information on inpatient DU at a national level from wholesalers/manufacturers. In Belgium, Italy and Portugal, drugs dispensed to patients in hospitals are registered at a national level. Data are freely available online only for Denmark and Iceland. From the PubMed search, of a total of 868 retrieved studies, only 13 studies used the ATC/DDD methodology. Although the number of DDD/100 bed-days was used in four studies, other units of measure were also used. The type of information provided for the inpatient sector allowed primarily for conducting DU research at an aggregated data level. The existence of national administrative structures to monitor hospital DU would contribute to promoting the rational use of medicines and improving the safety and quality of prescribing.

U2 - 10.1111/bcpt.12358

DO - 10.1111/bcpt.12358

M3 - Article

C2 - 25420967

SN - 1742-7843

VL - 116

JO - Basic & clinical pharmacology & toxicology

JF - Basic & clinical pharmacology & toxicology

IS - 3

ER -

Inpatient drug utilization in Europe: nationwide data sources and a review of publications on a selected group of medicines (PROTECT project).

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