Insect central nervous system gamma-aminobutyric acid.

S C Lummis; D B Sattelle

Insect central nervous system gamma-aminobutyric acid.

S C Lummis, D B Sattelle

Research output: Contribution to journal › Article › peer-review

Abstract

Specific saturable binding of radiolabelled gamma-aminobutyric acid (GABA) has been demonstrated in central nervous system (CNS) extracts of the cockroach, Periplaneta americana. The pharmacological properties of these putative insect CNS GABA receptors differ from those of both the vertebrate GABAA and GABAB receptor sites. Autoradiographical techniques have been used to examine the localization of these [3H]GABA binding sites in a cockroach ganglion and have shown that they are found predominantly in the neuropile, the region where the majority of synaptic connections occur. The results suggest that these insect CNS [3H]GABA binding sites may represent a novel class of GABA receptors.

Original language	English
Journal	Neuroscience letters
Volume	60
Issue number	1
Publication status	Published - 16 Sept 1985

Cite this

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title = "Insect central nervous system gamma-aminobutyric acid.",

abstract = "Specific saturable binding of radiolabelled gamma-aminobutyric acid (GABA) has been demonstrated in central nervous system (CNS) extracts of the cockroach, Periplaneta americana. The pharmacological properties of these putative insect CNS GABA receptors differ from those of both the vertebrate GABAA and GABAB receptor sites. Autoradiographical techniques have been used to examine the localization of these [3H]GABA binding sites in a cockroach ganglion and have shown that they are found predominantly in the neuropile, the region where the majority of synaptic connections occur. The results suggest that these insect CNS [3H]GABA binding sites may represent a novel class of GABA receptors.",

author = "Lummis, {S C} and Sattelle, {D B}",

year = "1985",

month = sep,

day = "16",

language = "English",

volume = "60",

journal = "Neuroscience letters",

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T1 - Insect central nervous system gamma-aminobutyric acid.

AU - Lummis, S C

AU - Sattelle, D B

PY - 1985/9/16

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N2 - Specific saturable binding of radiolabelled gamma-aminobutyric acid (GABA) has been demonstrated in central nervous system (CNS) extracts of the cockroach, Periplaneta americana. The pharmacological properties of these putative insect CNS GABA receptors differ from those of both the vertebrate GABAA and GABAB receptor sites. Autoradiographical techniques have been used to examine the localization of these [3H]GABA binding sites in a cockroach ganglion and have shown that they are found predominantly in the neuropile, the region where the majority of synaptic connections occur. The results suggest that these insect CNS [3H]GABA binding sites may represent a novel class of GABA receptors.

AB - Specific saturable binding of radiolabelled gamma-aminobutyric acid (GABA) has been demonstrated in central nervous system (CNS) extracts of the cockroach, Periplaneta americana. The pharmacological properties of these putative insect CNS GABA receptors differ from those of both the vertebrate GABAA and GABAB receptor sites. Autoradiographical techniques have been used to examine the localization of these [3H]GABA binding sites in a cockroach ganglion and have shown that they are found predominantly in the neuropile, the region where the majority of synaptic connections occur. The results suggest that these insect CNS [3H]GABA binding sites may represent a novel class of GABA receptors.

M3 - Article

C2 - 2997671

SN - 1872-7972

VL - 60

JO - Neuroscience letters

JF - Neuroscience letters

IS - 1

ER -

Insect central nervous system gamma-aminobutyric acid.

Abstract

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