Insertion of arynes into thioureas: A new amidine synthesis

Kallolmay Biswas, Michael F. Greaney

    Research output: Contribution to journalArticlepeer-review


    Arynes, generated from trimethylsilyl phenyltriflate precursors, have been found to react with thioureas via a formal π-insertion into the C=S bond. The reaction contrasts with that of ureas, which proceeds via benzyne σ-insertion into the C-N bond, and represents a new, operationally simple route to functionalized amidines. © 2011 American Chemical Society.
    Original languageEnglish
    Pages (from-to)4946-4949
    Number of pages3
    JournalOrganic Letters
    Issue number18
    Publication statusPublished - 16 Sep 2011


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