Insight into hypoglycemia frequency in congenital hyperinsulinism: evaluation of a large UK CGM dataset

Chris Worth, Yesica Tropeano, Pon Ramya Gokul, Karen E Cosgrove, Maria Salomon-Estebanez, Senthil Senniappan, Antonia Dastamani, Indraneel Banerjee

Research output: Contribution to journalArticlepeer-review


Introduction Hypoglycemia is often recurrent and severe in patients with congenital hyperinsulinism (CHI). However, there is little information regarding frequency or patterns of episodes to inform clinical management and future trial design. Research design and methods We aimed to describe frequency and patterns of hypoglycemia by varying thresholds through a large continuous glucose monitoring (CGM) dataset. Through the UK CHI centers of excellence, data were analyzed from patients with CHI over a 5-year period. Hypoglycemia thresholds of 3.0 (H3.0), 3.5 (H3.5) and 3.9 (H3.9) mmol/L were used to test threshold change on hypoglycemia frequencies. Results From 63 patients, 3.4 million data points, representing 32 years of monitoring, were analyzed. By UK consensus threshold H3.5, patients experienced a mean 1.3 hypoglycemic episodes per day. Per cent time hypoglycemic increased from 1.2% to 3.3% to 6.9% when threshold changed from H3.0 to H3.5 and H3.9. Merged data showed periodicity of hypoglycemia risk in 24-hour periods in all patients. Conclusions We have evaluated a large dataset to provide a comprehensive picture of the frequency and patterns of hypoglycemia for patients with CHI in the UK. These data establish a baseline risk of hypoglycemia by CGM and provide a framework for clinical management and clinical trial design.

Original languageEnglish
Article numbere002849
JournalBMJ open diabetes research & care
Issue number3
Publication statusPublished - 8 Jun 2022


  • blood glucose self-monitoring
  • hyperinsulinism
  • hypoglycemia


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