Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data

A. Stevens; C. Bonshek; A. Whatmore; I. Butcher; D. Hanson; C. De Leonibus; G. Shaikh; M. Brown; E. O'Shea; S. Victor; P. Powell; P. Settle; B. Padmakumar; A. Tan; E. Odeka; C. Cooper; J. Birch; A. Shenoy; M. Westwood; L. Patel; B. W. Dunn; P. Clayton

doi:10.1038/tpj.2014.4

Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data

A. Stevens, C. Bonshek, A. Whatmore, I. Butcher, D. Hanson, C. De Leonibus, G. Shaikh, M. Brown, E. O'Shea, S. Victor, P. Powell, P. Settle, B. Padmakumar, A. Tan, E. Odeka, C. Cooper, J. Birch, A. Shenoy, M. Westwood, L. PatelB. W. Dunn, P. Clayton

Research output: Contribution to journal › Article › peer-review

Abstract

Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in metabolism and gene expression profiles between CU and NCU at age 4-9 years. CU children (n=22) had greater height, weight and body mass index standard deviation scores along with insulin-like growth factor-I (IGF-I) and fasting glucose levels but lower adiponectin values than NCU children (n=11; all P

Original language	English
Pages (from-to)	376-384
Number of pages	8
Journal	Pharmacogenomics Journal
Volume	14
Issue number	4
DOIs	https://doi.org/10.1038/tpj.2014.4
Publication status	Published - 2014

Keywords

catch-up growth
metabolomics
network biology
SGA
transcriptomics

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Stevens, A., Bonshek, C., Whatmore, A., Butcher, I., Hanson, D., De Leonibus, C., Shaikh, G., Brown, M., O'Shea, E., Victor, S., Powell, P., Settle, P., Padmakumar, B., Tan, A., Odeka, E., Cooper, C., Birch, J., Shenoy, A., Westwood, M., ... Clayton, P. (2014). Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data. Pharmacogenomics Journal, 14(4), 376-384. https://doi.org/10.1038/tpj.2014.4

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title = "Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data",

abstract = "Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in metabolism and gene expression profiles between CU and NCU at age 4-9 years. CU children (n=22) had greater height, weight and body mass index standard deviation scores along with insulin-like growth factor-I (IGF-I) and fasting glucose levels but lower adiponectin values than NCU children (n=11; all P",

keywords = "catch-up growth, metabolomics, network biology, SGA, transcriptomics",

author = "A. Stevens and C. Bonshek and A. Whatmore and I. Butcher and D. Hanson and {De Leonibus}, C. and G. Shaikh and M. Brown and E. O'Shea and S. Victor and P. Powell and P. Settle and B. Padmakumar and A. Tan and E. Odeka and C. Cooper and J. Birch and A. Shenoy and M. Westwood and L. Patel and Dunn, {B. W.} and P. Clayton",

year = "2014",

doi = "10.1038/tpj.2014.4",

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pages = "376--384",

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Stevens, A, Bonshek, C, Whatmore, A, Butcher, I, Hanson, D, De Leonibus, C, Shaikh, G, Brown, M, O'Shea, E, Victor, S, Powell, P, Settle, P, Padmakumar, B, Tan, A, Odeka, E, Cooper, C, Birch, J, Shenoy, A, Westwood, M, Patel, L, Dunn, BW & Clayton, P 2014, 'Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data', Pharmacogenomics Journal, vol. 14, no. 4, pp. 376-384. https://doi.org/10.1038/tpj.2014.4

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AU - Stevens, A.

AU - Bonshek, C.

AU - Whatmore, A.

AU - Butcher, I.

AU - Hanson, D.

AU - De Leonibus, C.

AU - Shaikh, G.

AU - Brown, M.

AU - O'Shea, E.

AU - Victor, S.

AU - Powell, P.

AU - Settle, P.

AU - Padmakumar, B.

AU - Tan, A.

AU - Odeka, E.

AU - Cooper, C.

AU - Birch, J.

AU - Shenoy, A.

AU - Westwood, M.

AU - Patel, L.

AU - Dunn, B. W.

AU - Clayton, P.

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AB - Small for gestational age (SGA) children exhibiting catch-up (CU) growth have a greater risk of cardiometabolic diseases in later life compared with non-catch-up (NCU) SGA children. The aim of this study was to establish differences in metabolism and gene expression profiles between CU and NCU at age 4-9 years. CU children (n=22) had greater height, weight and body mass index standard deviation scores along with insulin-like growth factor-I (IGF-I) and fasting glucose levels but lower adiponectin values than NCU children (n=11; all P

KW - catch-up growth

KW - metabolomics

KW - network biology

KW - SGA

KW - transcriptomics

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DO - 10.1038/tpj.2014.4

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JF - Pharmacogenomics Journal

IS - 4

ER -

Insights into the pathophysiology of catch-up compared with non-catch-up growth in children born small for gestational age: An integrated analysis of metabolic and transcriptomic data

Abstract

Keywords

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