TY - JOUR
T1 - Insulin-like growth factors and their binding proteins in the circulation of patients with echinococcosis, trichinellosis and toxoplasmosis
AU - Baricevic-Jones, Ivona
AU - Nedić, Olgica
AU - Nikolić, Anna J.
AU - Baričević, Ivona
AU - Jovanović, Biljana
AU - Ilić, Nataša
PY - 2003/9
Y1 - 2003/9
N2 - Background: Insulin-like growth factors (IGFs) are polypeptide hormones that play anabolic roles in cellular growth and metabolism. Their activity is regulated by binding proteins (IGFBPs) and degradation mechanisms. The liver is regarded as the main source of circulating forms and the levels change in various disease states. The aim of the study was to explore the effects of parasitic infections on the circulating IGFs and IGFBPs. Methods: Peptide concentrations in sera of patients with echinococcosis, trichinellosis and toxoplasmosis were measured by radioimmunoassay, while IGFBP patterns were characterised by ligand-affinity blotting and gel chromatography. Results: IGF-I levels were reduced in trichinellosis (p=0.016), with the increased relative amounts of IGFBP-1, -2 and -4. The significantly reduced levels of IGF-I (p
AB - Background: Insulin-like growth factors (IGFs) are polypeptide hormones that play anabolic roles in cellular growth and metabolism. Their activity is regulated by binding proteins (IGFBPs) and degradation mechanisms. The liver is regarded as the main source of circulating forms and the levels change in various disease states. The aim of the study was to explore the effects of parasitic infections on the circulating IGFs and IGFBPs. Methods: Peptide concentrations in sera of patients with echinococcosis, trichinellosis and toxoplasmosis were measured by radioimmunoassay, while IGFBP patterns were characterised by ligand-affinity blotting and gel chromatography. Results: IGF-I levels were reduced in trichinellosis (p=0.016), with the increased relative amounts of IGFBP-1, -2 and -4. The significantly reduced levels of IGF-I (p
KW - Insulin-like growth factors
KW - Parasitic infections
U2 - 10.1016/S0009-8981(03)00282-1
DO - 10.1016/S0009-8981(03)00282-1
M3 - Article
SN - 0009-8981
VL - 335
SP - 83
EP - 88
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 1-2
ER -