Insulin-like growth factors and their binding proteins in the circulation of patients with echinococcosis, trichinellosis and toxoplasmosis

Ivona Baricevic-Jones, Olgica Nedić, Anna J. Nikolić, Ivona Baričević, Biljana Jovanović, Nataša Ilić

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Insulin-like growth factors (IGFs) are polypeptide hormones that play anabolic roles in cellular growth and metabolism. Their activity is regulated by binding proteins (IGFBPs) and degradation mechanisms. The liver is regarded as the main source of circulating forms and the levels change in various disease states. The aim of the study was to explore the effects of parasitic infections on the circulating IGFs and IGFBPs. Methods: Peptide concentrations in sera of patients with echinococcosis, trichinellosis and toxoplasmosis were measured by radioimmunoassay, while IGFBP patterns were characterised by ligand-affinity blotting and gel chromatography. Results: IGF-I levels were reduced in trichinellosis (p=0.016), with the increased relative amounts of IGFBP-1, -2 and -4. The significantly reduced levels of IGF-I (p
    Original languageEnglish
    Pages (from-to)83-88
    Number of pages5
    JournalClinica Chimica Acta
    Volume335
    Issue number1-2
    DOIs
    Publication statusPublished - Sept 2003

    Keywords

    • Insulin-like growth factors
    • Parasitic infections

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