Insulin therapy in pancreas donors as a predictor of subsequent transplant outcome

Iestyn Shapey; Angela Summers; Hussein Khambalia; Titus Augustine; Martin Rutter; David Van Dellen

Insulin therapy in pancreas donors as a predictor of subsequent transplant outcome

Iestyn Shapey, Angela Summers, Hussein Khambalia, Titus Augustine, Martin Rutter, David Van Dellen

Central Manchester University Hospitals NHS Foundation Trust

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Abstract

Introduction
•Brain stem death causes high levels of systemic catecholamines and inflammation affecting all organs.
•Hyperglycaemia following brain death is common and is managed with insulin in about half of all donors.
Aim
•We hypothesised that donor insulin use (DIU) is a marker of irreversible pancreatic beta-cell death.
•We aimed to assess relationships of DIU to pancreas transplant outcome and function.
Methods
Results
•National data from the UK Transplant registry (2004-2016) was reviewed retrospectively to determine donor variables associated with DIU and its relationship with graft survival.
•Early non-technical graft failure (transplant pancreatitis) was assessed from histology reports using our regional data.
•In a sub-group, we determined relationships between DIU and early c-peptide secretion.

Original language	English
Publication status	Published - 1 Mar 2017
Event	British Transplantation Society Annual Congress: BTS Harrogate - Harrogate, United Kingdom Duration: 1 Mar 2017 → 3 Mar 2017

Conference

Conference	British Transplantation Society Annual Congress
Abbreviated title	BTS 2017
Country/Territory	United Kingdom
City	Harrogate
Period	1/03/17 → 3/03/17

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Insulin therapy BTS poster v2

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title = "Insulin therapy in pancreas donors as a predictor of subsequent transplant outcome",

abstract = "Introduction•Brain stem death causes high levels of systemic catecholamines and inflammation affecting all organs.•Hyperglycaemia following brain death is common and is managed with insulin in about half of all donors.Aim•We hypothesised that donor insulin use (DIU) is a marker of irreversible pancreatic beta-cell death.•We aimed to assess relationships of DIU to pancreas transplant outcome and function.MethodsResults•National data from the UK Transplant registry (2004-2016) was reviewed retrospectively to determine donor variables associated with DIU and its relationship with graft survival.•Early non-technical graft failure (transplant pancreatitis) was assessed from histology reports using our regional data.•In a sub-group, we determined relationships between DIU and early c-peptide secretion.",

author = "Iestyn Shapey and Angela Summers and Hussein Khambalia and Titus Augustine and Martin Rutter and {Van Dellen}, David",

year = "2017",

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day = "1",

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note = "British Transplantation Society Annual Congress : BTS Harrogate, BTS 2017 ; Conference date: 01-03-2017 Through 03-03-2017",

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TY - CONF

T1 - Insulin therapy in pancreas donors as a predictor of subsequent transplant outcome

AU - Shapey, Iestyn

AU - Summers, Angela

AU - Khambalia, Hussein

AU - Augustine, Titus

AU - Rutter, Martin

AU - Van Dellen, David

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Introduction•Brain stem death causes high levels of systemic catecholamines and inflammation affecting all organs.•Hyperglycaemia following brain death is common and is managed with insulin in about half of all donors.Aim•We hypothesised that donor insulin use (DIU) is a marker of irreversible pancreatic beta-cell death.•We aimed to assess relationships of DIU to pancreas transplant outcome and function.MethodsResults•National data from the UK Transplant registry (2004-2016) was reviewed retrospectively to determine donor variables associated with DIU and its relationship with graft survival.•Early non-technical graft failure (transplant pancreatitis) was assessed from histology reports using our regional data.•In a sub-group, we determined relationships between DIU and early c-peptide secretion.

AB - Introduction•Brain stem death causes high levels of systemic catecholamines and inflammation affecting all organs.•Hyperglycaemia following brain death is common and is managed with insulin in about half of all donors.Aim•We hypothesised that donor insulin use (DIU) is a marker of irreversible pancreatic beta-cell death.•We aimed to assess relationships of DIU to pancreas transplant outcome and function.MethodsResults•National data from the UK Transplant registry (2004-2016) was reviewed retrospectively to determine donor variables associated with DIU and its relationship with graft survival.•Early non-technical graft failure (transplant pancreatitis) was assessed from histology reports using our regional data.•In a sub-group, we determined relationships between DIU and early c-peptide secretion.

M3 - Poster

T2 - British Transplantation Society Annual Congress

Y2 - 1 March 2017 through 3 March 2017

ER -

Insulin therapy in pancreas donors as a predictor of subsequent transplant outcome

Abstract

Conference

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