Integrin trafficking and the control of cell migration

Patrick T. Caswell, Jim C. Norman

    Research output: Contribution to journalArticlepeer-review


    In the late 1980s and early 1990s, the observation that certain integrin heterodimers are continually internalized from the plasma membrane into endosomal compartments and subsequently recycled back to the cell surface indicated that the endocytic and recycling pathways have the potential to exert minute-to-minute control over integrin function. This insight has prompted others to study the regulation of integrin trafficking in more detail. This review aims to summarize the findings of studies revealing the molecular mechanisms controlling integrin traffic, particularly those providing indications as to howthese processes contribute to cell migration and tumour cell invasiveness. © Blackwell Munksgaard, 2005.
    Original languageEnglish
    Pages (from-to)14-21
    Number of pages7
    JournalTraffic (Malden): the international journal of intracellular transport
    Issue number1
    Publication statusPublished - Jan 2006


    • Arf6
    • Cell migration
    • Endocytosis
    • GSK-3β
    • Integrin
    • Invadopopdia
    • PKC-ε
    • PKD1
    • Rab11
    • Rab25
    • Rab4
    • Recycling


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