Integrins in mechanotransduction

Tyler D Ross, Brian G Coon, Sanguk Yun, Nicolas Baeyens, Keiichiro Tanaka, Mingxing Ouyang, Martin A Schwartz

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects of forces on organs, tissues, and cells; and then discuss recent advances toward understanding molecular mechanisms.

    Original languageEnglish
    Pages (from-to)613-8
    Number of pages6
    JournalCurrent opinion in cell biology
    Volume25
    Issue number5
    DOIs
    Publication statusPublished - Oct 2013

    Keywords

    • Actin Cytoskeleton
    • Animals
    • Cell Adhesion
    • Extracellular Matrix
    • Humans
    • Integrins
    • Mechanotransduction, Cellular

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