Integrins: Masters and slaves of endocytic transport

Patrick T. Caswell, Suryakiran Vadrevu, Jim C. Norman

    Research output: Contribution to journalArticlepeer-review


    Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration. Furthermore, integrins can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis. © 2009 Macmillan Publishers Limited. All rights reserved.
    Original languageEnglish
    Pages (from-to)843-853
    Number of pages10
    JournalNature Reviews Molecular Cell Biology
    Issue number12
    Publication statusPublished - Dec 2009


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