Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source

Nicholas Weise; Syed Ahmed; Fabio Parmeggiani; Elina Siirola; Ahir Pushpanath; Ursula Schell; Nicholas Turner

doi:10.1039/C6CY00855K

Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source

Nicholas Weise, Syed Ahmed, Fabio Parmeggiani, Elina Siirola, Ahir Pushpanath, Ursula Schell, Nicholas Turner

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Abstract

An intensified, industrially-relevant strategy for the production of enantiopure halophenylalanines has been developed using the novel combination of a cyanobacterial phenylalanine ammonia lyase (PAL) and ammonium carbamate reaction buffer. The process boasts STYs up to >200 g L−1 d−1, ees ≥ 98% and simplified catalyst/reaction buffer preparation and work up.

Original language	Undefined
Pages (from-to)	4086-4089
Journal	Catalysis Science and Technology
Volume	6
Issue number	12
DOIs	https://doi.org/10.1039/C6CY00855K
Publication status	Published - 24 May 2016

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Cite this

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abstract = "An intensified, industrially-relevant strategy for the production of enantiopure halophenylalanines has been developed using the novel combination of a cyanobacterial phenylalanine ammonia lyase (PAL) and ammonium carbamate reaction buffer. The process boasts STYs up to >200 g L−1 d−1, ees ≥ 98% and simplified catalyst/reaction buffer preparation and work up.",

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AU - Weise, Nicholas

AU - Ahmed, Syed

AU - Parmeggiani, Fabio

AU - Siirola, Elina

AU - Pushpanath, Ahir

AU - Schell, Ursula

AU - Turner, Nicholas

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AB - An intensified, industrially-relevant strategy for the production of enantiopure halophenylalanines has been developed using the novel combination of a cyanobacterial phenylalanine ammonia lyase (PAL) and ammonium carbamate reaction buffer. The process boasts STYs up to >200 g L−1 d−1, ees ≥ 98% and simplified catalyst/reaction buffer preparation and work up.

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DO - 10.1039/C6CY00855K

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