Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis

Helen Young, Helen S. Young, Angela M. Summers, Ian R. Read, David A. Fairhurst, Darren J. Plant, Emanuela Campalani, Catherine H. Smith, Jonathan N W N Barker, Michael J. Detmar, Paul E C Brenchley, Christopher E M Griffiths

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and -460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+419) through which retinoids, an established systemic therapy for psoriasis, can block production of VEGF. We report that peripheral blood mononuclear cells (PBMCs) and epidermal keratinocytes (KC) from patients with psoriasis demonstrate differential, genotype-dependent, regulation of VEGF. For PBMCs, VEGF genotype distinguishes two groups of patients with psoriasis - "high and low VEGF producers" (P
    Original languageEnglish
    Pages (from-to)453-459
    Number of pages6
    JournalJournal of Investigative Dermatology
    Volume126
    Issue number2
    DOIs
    Publication statusPublished - Feb 2006

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