Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis

Helen Young; Helen S. Young; Angela M. Summers; Ian R. Read; David A. Fairhurst; Darren J. Plant; Emanuela Campalani; Catherine H. Smith; Jonathan N W N Barker; Michael J. Detmar; Paul E C Brenchley; Christopher E M Griffiths

doi:10.1038/sj.jid.5700096

Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis

Helen Young
, Helen S. Young
, Angela M. Summers
, Ian R. Read
, David A. Fairhurst
, Darren J. Plant
, Emanuela Campalani
, Catherine H. Smith
, Jonathan N W N Barker
, Michael J. Detmar
, Paul E C Brenchley
, Christopher E M Griffiths

Research output: Contribution to journal › Article › peer-review

Abstract

Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and -460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+419) through which retinoids, an established systemic therapy for psoriasis, can block production of VEGF. We report that peripheral blood mononuclear cells (PBMCs) and epidermal keratinocytes (KC) from patients with psoriasis demonstrate differential, genotype-dependent, regulation of VEGF. For PBMCs, VEGF genotype distinguishes two groups of patients with psoriasis - "high and low VEGF producers" (P

Original language	English
Pages (from-to)	453-459
Number of pages	6
Journal	Journal of Investigative Dermatology
Volume	126
Issue number	2
DOIs	https://doi.org/10.1038/sj.jid.5700096
Publication status	Published - Feb 2006

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Young, H., Young, H. S., Summers, A. M., Read, I. R., Fairhurst, D. A., Plant, D. J., Campalani, E., Smith, C. H., Barker, J. N. W. N., Detmar, M. J., Brenchley, P. E. C., & Griffiths, C. E. M. (2006). Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis. Journal of Investigative Dermatology, 126(2), 453-459. https://doi.org/10.1038/sj.jid.5700096

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title = "Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis",

abstract = "Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and -460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+419) through which retinoids, an established systemic therapy for psoriasis, can block production of VEGF. We report that peripheral blood mononuclear cells (PBMCs) and epidermal keratinocytes (KC) from patients with psoriasis demonstrate differential, genotype-dependent, regulation of VEGF. For PBMCs, VEGF genotype distinguishes two groups of patients with psoriasis - {"}high and low VEGF producers{"} (P",

author = "Helen Young and Young, \{Helen S.\} and Summers, \{Angela M.\} and Read, \{Ian R.\} and Fairhurst, \{David A.\} and Plant, \{Darren J.\} and Emanuela Campalani and Smith, \{Catherine H.\} and Barker, \{Jonathan N W N\} and Detmar, \{Michael J.\} and Brenchley, \{Paul E C\} and Griffiths, \{Christopher E M\}",

year = "2006",

month = feb,

doi = "10.1038/sj.jid.5700096",

language = "English",

volume = "126",

pages = "453--459",

journal = "Journal of Investigative Dermatology",

issn = "1523-1747",

publisher = "Elsevier BV",

number = "2",

}

Young, H, Young, HS, Summers, AM, Read, IR, Fairhurst, DA, Plant, DJ, Campalani, E, Smith, CH, Barker, JNWN, Detmar, MJ, Brenchley, PEC & Griffiths, CEM 2006, 'Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis', Journal of Investigative Dermatology, vol. 126, no. 2, pp. 453-459. https://doi.org/10.1038/sj.jid.5700096

TY - JOUR

T1 - Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis

AU - Young, Helen

AU - Young, Helen S.

AU - Summers, Angela M.

AU - Read, Ian R.

AU - Fairhurst, David A.

AU - Plant, Darren J.

AU - Campalani, Emanuela

AU - Smith, Catherine H.

AU - Barker, Jonathan N W N

AU - Detmar, Michael J.

AU - Brenchley, Paul E C

AU - Griffiths, Christopher E M

PY - 2006/2

Y1 - 2006/2

N2 - Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and -460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+419) through which retinoids, an established systemic therapy for psoriasis, can block production of VEGF. We report that peripheral blood mononuclear cells (PBMCs) and epidermal keratinocytes (KC) from patients with psoriasis demonstrate differential, genotype-dependent, regulation of VEGF. For PBMCs, VEGF genotype distinguishes two groups of patients with psoriasis - "high and low VEGF producers" (P

AB - Vascular endothelial growth factor (VEGF) promotes angiogenesis, and elevated levels are found in plaques of psoriasis. Two VEGF polymorphisms, +405 and -460, are associated with early-onset psoriasis and are close to the functional activator protein-1 site (+419) through which retinoids, an established systemic therapy for psoriasis, can block production of VEGF. We report that peripheral blood mononuclear cells (PBMCs) and epidermal keratinocytes (KC) from patients with psoriasis demonstrate differential, genotype-dependent, regulation of VEGF. For PBMCs, VEGF genotype distinguishes two groups of patients with psoriasis - "high and low VEGF producers" (P

U2 - 10.1038/sj.jid.5700096

DO - 10.1038/sj.jid.5700096

M3 - Article

SN - 1523-1747

VL - 126

SP - 453

EP - 459

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 2

ER -

Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis

Abstract

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