Interaction of [(dien)PtBr]Br with 6-oxopurine nucleosides

Vassiliki Theodorou, Anna Nicolaou, Nick Hadjiliadis

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    Complexes of the general formulae [(dien)Pt(nucl)]Br2, with nucl=guanosine (guo), inosine (ino), xanthosine (xao) and 9-methyl guanine (9-MeG) were first isolated from the reactions of [(dien)PtBr]Br with the nucleosides. Further reactions between the [(dien)Pt(nucl)]Br2, [(dien)PtBr]Br and K2PtX4 (XCl, Br) complexes produced new ones of formulae [(dien)Pt(nucl-H+)]Br, [{(dien)Pt}2(nucl-H+)](ClO40)3, [(dien)Pt(nucl-H+)PtX3] and [(dien)Pt(nucl)](PtX4) (XCl, Br). All complexes were characterized by elemental analysis, conductivity measurements, IR and 1H NMR spectra. All the nucleosides are firstly coordinated through their N7 atoms. This is followed by an attack of a second Pt(II) atom at N1, after deprotonation of this site in the dinuclear complexes. © 1993.
    Original languageEnglish
    Pages (from-to)91-94
    Number of pages3
    JournalInorganica Chimica Acta
    Issue number1
    Publication statusPublished - 1 Jun 1993


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