Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study

H. Chinoy, S. Adimulam, F. Marriage, P. New, M. Vincze, E. Zilahi, A. Kapitány, A. Gyetvai, L. Ekholm, P. Novota, M. Remakova, P. Charles, N. J. McHugh, L. Padyukov, L. Alfredsson, J. Vencovsky, I. E. Lundberg, K. Danko, W. E. Ollier, Robert G. Cooper

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    Abstract

    Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p
    Original languageEnglish
    Pages (from-to)961-965
    Number of pages4
    JournalAnnals of the rheumatic diseases
    Volume71
    Issue number6
    DOIs
    Publication statusPublished - Jun 2012

    Keywords

    • Myositis
    • antibodies
    • smoking
    • gene-environment interactions
    • HLA

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