Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study

H. Chinoy; S. Adimulam; F. Marriage; P. New; M. Vincze; E. Zilahi; A. Kapitány; A. Gyetvai; L. Ekholm; P. Novota; M. Remakova; P. Charles; N. J. McHugh; L. Padyukov; L. Alfredsson; J. Vencovsky; I. E. Lundberg; K. Danko; W. E. Ollier; Robert G. Cooper

doi:10.1136/annrheumdis-2011-200182

Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study

H. Chinoy, S. Adimulam, F. Marriage, P. New, M. Vincze, E. Zilahi, A. Kapitány, A. Gyetvai, L. Ekholm, P. Novota, M. Remakova, P. Charles, N. J. McHugh, L. Padyukov, L. Alfredsson, J. Vencovsky, I. E. Lundberg, K. Danko, W. E. Ollier, Robert G. Cooper

Research output: Contribution to journal › Article › peer-review

41 Downloads (Pure)

Abstract

Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p

Original language	English
Pages (from-to)	961-965
Number of pages	4
Journal	Annals of the rheumatic diseases
Volume	71
Issue number	6
DOIs	https://doi.org/10.1136/annrheumdis-2011-200182
Publication status	Published - Jun 2012

Keywords

Myositis
antibodies
smoking
gene-environment interactions
HLA

Access to Document

10.1136/annrheumdis-2011-200182

POST-PEER-REVIEW-NON-PUBLISHERS.DOCAccepted author manuscript, 252 KB

Cite this

Chinoy, H., Adimulam, S., Marriage, F., New, P., Vincze, M., Zilahi, E., Kapitány, A., Gyetvai, A., Ekholm, L., Novota, P., Remakova, M., Charles, P., McHugh, N. J., Padyukov, L., Alfredsson, L., Vencovsky, J., Lundberg, I. E., Danko, K., Ollier, W. E., & Cooper, R. G. (2012). Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study. Annals of the rheumatic diseases, 71(6), 961-965. https://doi.org/10.1136/annrheumdis-2011-200182

@article{050abe35f78943b18f7a4fbc8ffc5e0f,

title = "Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study",

abstract = "Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p",

keywords = "Myositis, antibodies, smoking, gene-environment interactions, HLA",

author = "H. Chinoy and S. Adimulam and F. Marriage and P. New and M. Vincze and E. Zilahi and A. Kapit{\'a}ny and A. Gyetvai and L. Ekholm and P. Novota and M. Remakova and P. Charles and McHugh, {N. J.} and L. Padyukov and L. Alfredsson and J. Vencovsky and Lundberg, {I. E.} and K. Danko and Ollier, {W. E.} and Cooper, {Robert G.}",

year = "2012",

month = jun,

doi = "10.1136/annrheumdis-2011-200182",

language = "English",

volume = "71",

pages = "961--965",

journal = "Annals of the rheumatic diseases",

issn = "0003-4967",

publisher = "Elsevier BV",

number = "6",

}

Chinoy, H, Adimulam, S, Marriage, F, New, P, Vincze, M, Zilahi, E, Kapitány, A, Gyetvai, A, Ekholm, L, Novota, P, Remakova, M, Charles, P, McHugh, NJ, Padyukov, L, Alfredsson, L, Vencovsky, J, Lundberg, IE, Danko, K, Ollier, WE & Cooper, RG 2012, 'Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study', Annals of the rheumatic diseases, vol. 71, no. 6, pp. 961-965. https://doi.org/10.1136/annrheumdis-2011-200182

TY - JOUR

T1 - Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study

AU - Chinoy, H.

AU - Adimulam, S.

AU - Marriage, F.

AU - New, P.

AU - Vincze, M.

AU - Zilahi, E.

AU - Kapitány, A.

AU - Gyetvai, A.

AU - Ekholm, L.

AU - Novota, P.

AU - Remakova, M.

AU - Charles, P.

AU - McHugh, N. J.

AU - Padyukov, L.

AU - Alfredsson, L.

AU - Vencovsky, J.

AU - Lundberg, I. E.

AU - Danko, K.

AU - Ollier, W. E.

AU - Cooper, Robert G.

PY - 2012/6

Y1 - 2012/6

N2 - Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p

AB - Objectives: HLA-DRB1*03 is strongly associated with anti-Jo-1-positive idiopathic inflammatory myopathies (IIM) and there is now increasing evidence that Jo-1 antigen is preferentially expressed in lung tissue. This study examined whether smoking was associated with the development of anti-Jo-1 antibodies in HLA-DRB1*03-positive IIM. Methods: IIM cases were selected with concurrent information regarding HLA-DRB1 status, smoking history and anti-Jo-1 antibody status. DNA was genotyped at DRB1 using a commercial sequence-specific oligonucleotide kit. Anti-Jo-1 antibody status was established using a line blot assay or immunoprecipitation. Results: 557 Caucasian IIM patients were recruited from Hungary (181), UK (99), Sweden (94) and Czech Republic (183). Smoking frequency was increased in anti-Jo-1- positive IIM cases, and reached statistical significance in Hungarian IIM (45% Jo-1-positive vs 17% Jo-1-negative, OR 3.94, 95% CI 1.53 to 9.89, p

KW - Myositis

KW - antibodies

KW - smoking

KW - gene-environment interactions

KW - HLA

U2 - 10.1136/annrheumdis-2011-200182

DO - 10.1136/annrheumdis-2011-200182

M3 - Article

C2 - 22186711

SN - 0003-4967

VL - 71

SP - 961

EP - 965

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 6

ER -

Interaction of HLA-DRB1*03 and smoking for the development of anti-Jo-1 antibodies in adult idiopathic inflammatory myopathies: A European-wide case study

Abstract

Keywords

Access to Document

Fingerprint

Cite this