Interaction of the thiol-dependent reductase ERp57 with nascent glycoproteins

Jason D. Oliver, Fimme J. Van Der Wal, Neil J. Bulleid, Stephen High

Research output: Contribution to journalArticlepeer-review


Calnexin and calreticulin interact specifically with newly synthesized glycoproteins in the endoplasmic reticulum (ER) and function as molecular chaperones. The carbohydrate-specific interactions between ER components and glycoproteins synthesized in isolated canine pancreatic microsomes were analyzed using a cross-linking approach. A carbohydrate-dependent interaction between newly synthesized glycoproteins, the thiol-dependent reductase ERp57, and either calnexin or calreticulin was identified. The interaction between ERp57 and the newly synthesized glycoproteins required trimming of the N- linked oligosaccharide side chain. Thus, it is likely that ERp57 functions as part of the glycoprotein-specific quality control machinery operating in the lumen of the ER.
Original languageEnglish
Pages (from-to)86-88
Number of pages2
Issue number5296
Publication statusPublished - 3 Jan 1997


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