Interactions of the IGF system with diabetes and its vascular complications

R. P. Narayanan; K. W. Siddals; A. H. Heald; J. M. Gibson

doi:10.1055/s-0032-1333233

Interactions of the IGF system with diabetes and its vascular complications

R. P. Narayanan, K. W. Siddals, A. H. Heald, J. M. Gibson

Division of Diabetes, Endocrinology & Gastroenterology (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

The insulin-like growth factor (IGF) system is an evolutionarily conserved group of important proteins that are fundamental to life. Indeed, insulin can be viewed as simply a specialized arm of the IGF system that has evolved to regulate primarily metabolic functions. The main purpose of the IGF system is to form a highly refined mechanism for the control of cellular growth, metabolism and survival. Dysregulation of such a system can have serious consequences. In this review we have focussed on the IGF system and its relation to diabetes and the development of cardiometabolic disorders.

Original language	English
Pages (from-to)	255-261
Number of pages	7
Journal	Experimental and Clinical Endocrinology and Diabetes
Volume	121
Issue number	5
DOIs	https://doi.org/10.1055/s-0032-1333233
Publication status	Published - 25 Feb 2013

Keywords

cardiovascular
IGF
metabolic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1055/s-0032-1333233

Cite this

@article{cc82b52724fc422f8980b13ca4b9d861,

title = "Interactions of the IGF system with diabetes and its vascular complications",

abstract = "The insulin-like growth factor (IGF) system is an evolutionarily conserved group of important proteins that are fundamental to life. Indeed, insulin can be viewed as simply a specialized arm of the IGF system that has evolved to regulate primarily metabolic functions. The main purpose of the IGF system is to form a highly refined mechanism for the control of cellular growth, metabolism and survival. Dysregulation of such a system can have serious consequences. In this review we have focussed on the IGF system and its relation to diabetes and the development of cardiometabolic disorders.",

keywords = "cardiovascular, IGF, metabolic",

author = "Narayanan, {R. P.} and Siddals, {K. W.} and Heald, {A. H.} and Gibson, {J. M.}",

year = "2013",

month = feb,

day = "25",

doi = "10.1055/s-0032-1333233",

language = "English",

volume = "121",

pages = "255--261",

journal = "Experimental and Clinical Endocrinology and Diabetes",

issn = "0947-7349",

publisher = "Georg Thieme Verlag",

number = "5",

}

TY - JOUR

T1 - Interactions of the IGF system with diabetes and its vascular complications

AU - Narayanan, R. P.

AU - Siddals, K. W.

AU - Heald, A. H.

AU - Gibson, J. M.

PY - 2013/2/25

Y1 - 2013/2/25

N2 - The insulin-like growth factor (IGF) system is an evolutionarily conserved group of important proteins that are fundamental to life. Indeed, insulin can be viewed as simply a specialized arm of the IGF system that has evolved to regulate primarily metabolic functions. The main purpose of the IGF system is to form a highly refined mechanism for the control of cellular growth, metabolism and survival. Dysregulation of such a system can have serious consequences. In this review we have focussed on the IGF system and its relation to diabetes and the development of cardiometabolic disorders.

AB - The insulin-like growth factor (IGF) system is an evolutionarily conserved group of important proteins that are fundamental to life. Indeed, insulin can be viewed as simply a specialized arm of the IGF system that has evolved to regulate primarily metabolic functions. The main purpose of the IGF system is to form a highly refined mechanism for the control of cellular growth, metabolism and survival. Dysregulation of such a system can have serious consequences. In this review we have focussed on the IGF system and its relation to diabetes and the development of cardiometabolic disorders.

KW - cardiovascular

KW - IGF

KW - metabolic

UR - http://www.scopus.com/inward/record.url?scp=84877825915&partnerID=8YFLogxK

U2 - 10.1055/s-0032-1333233

DO - 10.1055/s-0032-1333233

M3 - Review article

C2 - 23430576

AN - SCOPUS:84877825915

SN - 0947-7349

VL - 121

SP - 255

EP - 261

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

IS - 5

ER -

Interactions of the IGF system with diabetes and its vascular complications

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this