Interfacing functionalized carbon nanohorns with primary phagocytic cells

Stéphanie Lacotte, Ainara García, Marion Décossas, Wafa T. Al-Jamal, Shouping Li, Kostas Kostarelos, Sylviane Muller, Maurizio Prato, Hélène Dumortier, Alberto Bianco

    Research output: Contribution to journalArticlepeer-review


    The biocompatibility of functionalized carbon nanohorns (f-CNH) was analyzed regarding primary phagocytic cells. Fluorescein isothiocyanate-labeled (FITC) f-CNHs were incubated with primary peritoneal mouse macrophages for different periods of time to analyze whether macrophages can sense and internalize f-CNHs. It was found using confocal microscopy that f-CNHs were not detected in all the cells after 24 hours of incubation. The investigation revealed that f-CNHs can be obtained by a direct addition to pristine CNHs of a diamine moiety that can be further modified through a fluorescent probe, resulting in biocompatible f-CNHs. The results show that the delivery of biologically active agents using f-CNHs that internalize into cells and promote contemporarily the activation of the immune system, is a very encouraging concept.
    Original languageEnglish
    Pages (from-to)2421-2426
    Number of pages5
    JournalAdvanced Materials
    Issue number12
    Publication statusPublished - 18 Jun 2008


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