Interhemispheric transfer time in patients with auditory hallucinations: An auditory event-related potential study

Katherine R. Henshall, Alex A. Sergejew, Colette M. McKay, Gary Rance, Tracey L. Shea, Melissa J. Hayden, Hamish Innes-Brown, David L. Copolov

    Research output: Contribution to journalArticlepeer-review


    Central auditory processing in schizophrenia patients with a history of auditory hallucinations has been reported to be impaired, and abnormalities of interhemispheric transfer have been implicated in these patients. This study examined interhemispheric functional connectivity between auditory cortical regions, using temporal information obtained from latency measures of the auditory N1 evoked potential. Interhemispheric Transfer Times (IHTTs) were compared across 3 subject groups: schizophrenia patients who had experienced auditory hallucinations, schizophrenia patients without a history of auditory hallucinations, and normal controls. Pure tones and single-syllable words were presented monaurally to each ear, while EEG was recorded continuously. IHTT was calculated for each stimulus type by comparing the latencies of the auditory N1 evoked potential recorded contralaterally and ipsilaterally to the ear of stimulation. The IHTTs for pure tones did not differ between groups. For word stimuli, the IHTT was significantly different across the 3 groups: the IHTT was close to zero in normal controls, was highest in the AH group, and was negative (shorter latencies ipsilaterally) in the nonAH group. Differences in IHTTs may be attributed to transcallosal dysfunction in the AH group, but altered or reversed cerebral lateralization in nonAH participants is also possible. © 2012 Elsevier B.V..
    Original languageEnglish
    Pages (from-to)130-139
    Number of pages9
    JournalInternational Journal of Psychophysiology
    Issue number2
    Publication statusPublished - May 2012


    • Auditory cortex
    • Auditory hallucinations
    • Auditory N1 event-related potential (ERP)
    • Interhemispheric transfer
    • Schizophrenia


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