Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome

G Coakley; C C  Mok; A H  Hajeer; William Ollier; D Turner; P J  Sinnott; I V  Hutchinson; G S  Panayi; J S  Lanchbury

Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome

G Coakley
, C C Mok
, A H Hajeer
, William Ollier
, D Turner
, P J Sinnott
, I V Hutchinson
, G S Panayi
, J S Lanchbury

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions

Original language	English
Pages (from-to)	988-991
Number of pages	4
Journal	British Journal of Rheumatology
Volume	37
Issue number	9
Publication status	Published - 1998

Keywords

ACADEMIC JOURNAL PAPERS
ORIGINAL ARTICLES

Cite this

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title = "Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome",

abstract = "OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions",

keywords = "ACADEMIC JOURNAL PAPERS, ORIGINAL ARTICLES",

author = "G Coakley and Mok, \{C C\} and Hajeer, \{A H\} and William Ollier and D Turner and Sinnott, \{P J\} and Hutchinson, \{I V\} and Panayi, \{G S\} and Lanchbury, \{J S\}",

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language = "English",

volume = "37",

pages = "988--991",

journal = "British Journal of Rheumatology",

issn = "1460-2172",

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TY - JOUR

T1 - Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome

AU - Coakley, G

AU - Mok, C C

AU - Hajeer, A H

AU - Ollier, William

AU - Turner, D

AU - Sinnott, P J

AU - Hutchinson, I V

AU - Panayi, G S

AU - Lanchbury, J S

N1 - UI - 98455086 LA - eng RN - 130068-27-8 (Interleukin-10) PT - Journal Article DA - 19981027 IS - 0263-7103 SB - AIM SB - IM CY - ENGLAND

PY - 1998

Y1 - 1998

N2 - OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions

AB - OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions

KW - ACADEMIC JOURNAL PAPERS

KW - ORIGINAL ARTICLES

M3 - Article

SN - 1460-2172

VL - 37

SP - 988

EP - 991

JO - British Journal of Rheumatology

JF - British Journal of Rheumatology

IS - 9

ER -

Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome

Abstract

Keywords

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