International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease

Max A. Laansma, Joanna K. Bright, Sarah Al-Bachari, Tim J. Anderson, Tyler Ard, Francesca Assogna, Katherine A. Baquero, Henk W. Berendse, Jamie Blair, Fernando Cendes, John C. Dalrymple-Alford, Rob M.A. de Bie, Ines Debove, Michiel F. Dirkx, Jason Druzgal, Hedley C.A. Emsley, Gäetan Garraux, Rachel P. Guimarães, Boris A. Gutman, Rick C. HelmichJohannes C. Klein, Clare E. Mackay, Corey T. McMillan, Tracy R. Melzer, Laura M. Parkes, Fabrizio Piras, Toni L. Pitcher, Kathleen L. Poston, Mario Rango, Letícia F. Ribeiro, Cristiane S. Rocha, Christian Rummel, Lucas S.R. Santos, Reinhold Schmidt, Petra Schwingenschuh, Gianfranco Spalletta, Letizia Squarcina, Odile A. van den Heuvel, Chris Vriend, Jiun Jie Wang, Daniel Weintraub, Roland Wiest, Clarissa L. Yasuda, Neda Jahanshad, Paul M. Thompson, Ysbrand D. van der Werf

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage-specific profiles of pathology, as suggested by in vivo neuroimaging. Methods: Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed-effects models. Patients grouped according to Hoehn and Yahr stage were compared with age- and sex-matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. Results: Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls (dmax = −0.20, dmin = −0.09). The bilateral putamen (dleft = −0.14, dright = −0.14) and left amygdala (d = −0.13) were smaller in patients, whereas the left thalamus was larger (d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. Conclusions: Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Original languageEnglish
Pages (from-to)2583-2594
Number of pages12
JournalMovement Disorders
Volume36
Issue number11
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • ENIGMA
  • MRI
  • Parkinson's disease
  • brain
  • disease severity

Research Beacons, Institutes and Platforms

  • Manchester Institute for Collaborative Research on Ageing

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