InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers

Freddy Sitas; Sam Egger; Margaret I. Urban; Philip R. Taylor; Christian C. Abnet; Paolo Boffetta; Dianne L. O'Connell; David C. Whiteman; Paul Brennan; Reza Malekzadeh; Michael Pawlita; Sanford M. Dawsey; Tim Waterboer; Penelope M. Webb; Adèle C. Green; Nicholas K. Hayward; David Zaridze; Ivana Holcatova; Dana Mates; Neonila Szeszenia-Dabrowska; Gilles Ferro; Vladimir Janout; Maria Paula Curado; Ana Maria Menezes; Sergio Koifman; Farhad Islami; Dariush Nasrollahzadeh; Nan Hu; Alisa M. Goldstein; Ying Gao; Ti Ding; Farin Kamangar

doi:10.1093/jnci/djr499

InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers

Freddy Sitas, Sam Egger, Margaret I. Urban, Philip R. Taylor, Christian C. Abnet, Paolo Boffetta, Dianne L. O'Connell, David C. Whiteman, Paul Brennan, Reza Malekzadeh, Michael Pawlita, Sanford M. Dawsey, Tim Waterboer, Penelope M. Webb, Adèle C. Green, Nicholas K. Hayward, David Zaridze, Ivana Holcatova, Dana Mates, Neonila Szeszenia-DabrowskaGilles Ferro, Vladimir Janout, Maria Paula Curado, Ana Maria Menezes, Sergio Koifman, Farhad Islami, Dariush Nasrollahzadeh, Nan Hu, Alisa M. Goldstein, Ying Gao, Ti Ding, Farin Kamangar

Research output: Contribution to journal › Article › peer-review

Abstract

Background The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing Background risks of esophageal cancer. Methods We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided. ResultsWe found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, P =. 023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, P

Original language	English
Pages (from-to)	147-158
Number of pages	11
Journal	Journal of the National Cancer Institute
Volume	104
Issue number	2
DOIs	https://doi.org/10.1093/jnci/djr499
Publication status	Published - 18 Jan 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/jnci/djr499

Cite this

Sitas, F., Egger, S., Urban, M. I., Taylor, P. R., Abnet, C. C., Boffetta, P., O'Connell, D. L., Whiteman, D. C., Brennan, P., Malekzadeh, R., Pawlita, M., Dawsey, S. M., Waterboer, T., Webb, P. M., Green, A. C., Hayward, N. K., Zaridze, D., Holcatova, I., Mates, D., ... Kamangar, F. (2012). InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers. Journal of the National Cancer Institute, 104(2), 147-158. https://doi.org/10.1093/jnci/djr499

@article{4089da0ab346476e9edeaf3d195ff0e4,

title = "InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers",

abstract = "Background The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing Background risks of esophageal cancer. Methods We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided. ResultsWe found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, P =. 023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, P",

author = "Freddy Sitas and Sam Egger and Urban, {Margaret I.} and Taylor, {Philip R.} and Abnet, {Christian C.} and Paolo Boffetta and O'Connell, {Dianne L.} and Whiteman, {David C.} and Paul Brennan and Reza Malekzadeh and Michael Pawlita and Dawsey, {Sanford M.} and Tim Waterboer and Webb, {Penelope M.} and Green, {Ad{\`e}le C.} and Hayward, {Nicholas K.} and David Zaridze and Ivana Holcatova and Dana Mates and Neonila Szeszenia-Dabrowska and Gilles Ferro and Vladimir Janout and Curado, {Maria Paula} and Menezes, {Ana Maria} and Sergio Koifman and Farhad Islami and Dariush Nasrollahzadeh and Nan Hu and Goldstein, {Alisa M.} and Ying Gao and Ti Ding and Farin Kamangar",

note = "N02-SC-66211, NCI NIH HHS, United States, Cancer Research UK, United Kingdom",

year = "2012",

month = jan,

day = "18",

doi = "10.1093/jnci/djr499",

language = "English",

volume = "104",

pages = "147--158",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "2",

}

Sitas, F, Egger, S, Urban, MI, Taylor, PR, Abnet, CC, Boffetta, P, O'Connell, DL, Whiteman, DC, Brennan, P, Malekzadeh, R, Pawlita, M, Dawsey, SM, Waterboer, T, Webb, PM, Green, AC, Hayward, NK, Zaridze, D, Holcatova, I, Mates, D, Szeszenia-Dabrowska, N, Ferro, G, Janout, V, Curado, MP, Menezes, AM, Koifman, S, Islami, F, Nasrollahzadeh, D, Hu, N, Goldstein, AM, Gao, Y, Ding, T & Kamangar, F 2012, 'InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers', Journal of the National Cancer Institute, vol. 104, no. 2, pp. 147-158. https://doi.org/10.1093/jnci/djr499

TY - JOUR

T1 - InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers

AU - Sitas, Freddy

AU - Egger, Sam

AU - Urban, Margaret I.

AU - Taylor, Philip R.

AU - Abnet, Christian C.

AU - Boffetta, Paolo

AU - O'Connell, Dianne L.

AU - Whiteman, David C.

AU - Brennan, Paul

AU - Malekzadeh, Reza

AU - Pawlita, Michael

AU - Dawsey, Sanford M.

AU - Waterboer, Tim

AU - Webb, Penelope M.

AU - Green, Adèle C.

AU - Hayward, Nicholas K.

AU - Zaridze, David

AU - Holcatova, Ivana

AU - Mates, Dana

AU - Szeszenia-Dabrowska, Neonila

AU - Ferro, Gilles

AU - Janout, Vladimir

AU - Curado, Maria Paula

AU - Menezes, Ana Maria

AU - Koifman, Sergio

AU - Islami, Farhad

AU - Nasrollahzadeh, Dariush

AU - Hu, Nan

AU - Goldstein, Alisa M.

AU - Gao, Ying

AU - Ding, Ti

AU - Kamangar, Farin

N1 - N02-SC-66211, NCI NIH HHS, United States, Cancer Research UK, United Kingdom

PY - 2012/1/18

Y1 - 2012/1/18

N2 - Background The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing Background risks of esophageal cancer. Methods We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided. ResultsWe found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, P =. 023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, P

AB - Background The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing Background risks of esophageal cancer. Methods We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logistic regression with adjustment for smoking, alcohol consumption, and other potential confounders. Pooled odds ratios and 95% confidence intervals were calculated using either a linear mixed-effects approach or a joint fixed-effects approach. All statistical tests were two-sided. ResultsWe found statistically significant associations between esophageal squamous cell carcinoma and antibodies to E6 for HPV16 (OR = 1.89, 95% CI = 1.09 to 3.29, P =. 023) and HPV6 (OR = 2.53, 95% CI = 1.51 to 4.25, P

U2 - 10.1093/jnci/djr499

DO - 10.1093/jnci/djr499

M3 - Article

C2 - 22228147

SN - 0027-8874

VL - 104

SP - 147

EP - 158

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 2

ER -

InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this