Interstitial diffusion of macromolecules in solid tumors: Role of the interstitial matrix

Yves Boucher, Alain Pluen, Saroja Ramanujan, Trevor D. Mckee, Rakesh K. Jain

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Interstitial diffusion of macromolecules in solid tumors was investigated. Xenografts were implanted in the dorsal chamber or cranial window in mice and the interstitial diffusion of different size molecules was measured with the fluorescence recovery after photobleaching (FRAP) technique. The diffusion coefficients were related to the distribution and relative levels of HA, decorin and collagen type I and the organization of fibrillar collagen.
    Original languageEnglish
    Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED|ASME Bioeng Div Publ BED
    EditorsR.D. Kamm, G.W. Schmid-Schoenbein, G.A. Atesian, M.S. Hefzy
    Pages97-98
    Number of pages1
    Volume50
    Publication statusPublished - 2001
    EventProceedings of the 2001 Bioengineering Conference - Snowbird, UT
    Duration: 1 Jul 2001 → …

    Conference

    ConferenceProceedings of the 2001 Bioengineering Conference
    CitySnowbird, UT
    Period1/07/01 → …

    Fingerprint

    Dive into the research topics of 'Interstitial diffusion of macromolecules in solid tumors: Role of the interstitial matrix'. Together they form a unique fingerprint.

    Cite this