Intestinal stents: Structure, functionalization and advanced engineering innovation

Yusheng Feng; Yufeng Chen; Ying Chen; Xiaowen He; Yousef Khan; Hong Hu; Ping Lan; Yi Li; Xiaoqin Wang; Gang Li; David Kaplan

doi:10.1016/j.bioadv.2022.212810

Intestinal stents: Structure, functionalization and advanced engineering innovation

Yusheng Feng, Yufeng Chen, Ying Chen, Xiaowen He, Yousef Khan, Hong Hu, Ping Lan, Yi Li, Xiaoqin Wang, Gang Li, David Kaplan

Tufts University

Research output: Contribution to journal › Article › peer-review

Abstract

Intestinal stents are a palliative treatment option that solves many shortcomings of traditional surgeries for cancer-induced intestinal obstructions. The present review provides an overview of the incidence, clinical manifestations and limitations in the treatment of intestinal cancers. The paper also discusses material property requirements, indications, complications and the future of stent-assisted therapy. The advantages and disadvantages of different materials and processing techniques for intestinal stents are reviewed along with new stent treatment combinations for colorectal cancer. Challenges that require further cooperative studies are also detailed. The future development of intestinal stents will depend on innovation in material designs as well as the utilization of multi-functional strategies and innovative engineering solutions.

Original language	English
Article number	212810
Journal	Biomaterials Advances
Volume	137
Early online date	29 Apr 2022
DOIs	https://doi.org/10.1016/j.bioadv.2022.212810
Publication status	Published - 1 Jun 2022

Keywords

Intestinal stents
Colorectal cancer
Drug delivery
Biodegradable
Functionalization

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bioadv.2022.212810

Cite this

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title = "Intestinal stents: Structure, functionalization and advanced engineering innovation",

abstract = "Intestinal stents are a palliative treatment option that solves many shortcomings of traditional surgeries for cancer-induced intestinal obstructions. The present review provides an overview of the incidence, clinical manifestations and limitations in the treatment of intestinal cancers. The paper also discusses material property requirements, indications, complications and the future of stent-assisted therapy. The advantages and disadvantages of different materials and processing techniques for intestinal stents are reviewed along with new stent treatment combinations for colorectal cancer. Challenges that require further cooperative studies are also detailed. The future development of intestinal stents will depend on innovation in material designs as well as the utilization of multi-functional strategies and innovative engineering solutions.",

keywords = "Intestinal stents, Colorectal cancer, Drug delivery, Biodegradable, Functionalization",

author = "Yusheng Feng and Yufeng Chen and Ying Chen and Xiaowen He and Yousef Khan and Hong Hu and Ping Lan and Yi Li and Xiaoqin Wang and Gang Li and David Kaplan",

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T2 - Structure, functionalization and advanced engineering innovation

AU - Feng, Yusheng

AU - Chen, Yufeng

AU - Chen, Ying

AU - He, Xiaowen

AU - Khan, Yousef

AU - Hu, Hong

AU - Lan, Ping

AU - Li, Yi

AU - Wang, Xiaoqin

AU - Li, Gang

AU - Kaplan, David

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Intestinal stents are a palliative treatment option that solves many shortcomings of traditional surgeries for cancer-induced intestinal obstructions. The present review provides an overview of the incidence, clinical manifestations and limitations in the treatment of intestinal cancers. The paper also discusses material property requirements, indications, complications and the future of stent-assisted therapy. The advantages and disadvantages of different materials and processing techniques for intestinal stents are reviewed along with new stent treatment combinations for colorectal cancer. Challenges that require further cooperative studies are also detailed. The future development of intestinal stents will depend on innovation in material designs as well as the utilization of multi-functional strategies and innovative engineering solutions.

AB - Intestinal stents are a palliative treatment option that solves many shortcomings of traditional surgeries for cancer-induced intestinal obstructions. The present review provides an overview of the incidence, clinical manifestations and limitations in the treatment of intestinal cancers. The paper also discusses material property requirements, indications, complications and the future of stent-assisted therapy. The advantages and disadvantages of different materials and processing techniques for intestinal stents are reviewed along with new stent treatment combinations for colorectal cancer. Challenges that require further cooperative studies are also detailed. The future development of intestinal stents will depend on innovation in material designs as well as the utilization of multi-functional strategies and innovative engineering solutions.

KW - Intestinal stents

KW - Colorectal cancer

KW - Drug delivery

KW - Biodegradable

KW - Functionalization

U2 - 10.1016/j.bioadv.2022.212810

DO - 10.1016/j.bioadv.2022.212810

M3 - Article

SN - 2772-9508

VL - 137

JO - Biomaterials Advances

JF - Biomaterials Advances

M1 - 212810

ER -

Intestinal stents: Structure, functionalization and advanced engineering innovation

Abstract

Keywords

UN SDGs

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