Intrauterine programming of urinary calcium and magnesium excretion in children born to mothers with insulin dependent diabetes mellitus

M. Z. Mughal; J. A. Eelloo; S. A. Roberts; S. Sibartie; M. Maresh; C. P. Sibley; J. E. Adams

doi:10.1136/adc.2004.052795

Intrauterine programming of urinary calcium and magnesium excretion in children born to mothers with insulin dependent diabetes mellitus

M. Z. Mughal, J. A. Eelloo, S. A. Roberts, S. Sibartie, M. Maresh, C. P. Sibley, J. E. Adams

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Offspring of diabetic rats have reduced urinary calcium and magnesium excretion compared with offspring of controls; these differences persist up to 16 weeks after birth, a time equivalent to young adulthood in humans. Objectives: To test the hypothesis that urinary calcium and magnesium excretion would be lower in children born to mothers with insulin dependent diabetes mellitus (ChMIDDM) than those born to nondiabetic mothers. Methods: Concentrations of calcium, magnesium, sodium, and creatinine were measured in first void spot urine samples collected from 45 (28 male; median age 9.6 years) ChMIDDM and 127 (58 male; median age 11.3 years) controls. Analysis of covariance was used to test for differences in urinary calcium to creatinine ratios (UCa/Cr), magnesium to creatinine ratios (UMg/Cr), and log sodium to creatinine ratios (logUNa/Cr) between controls and ChMIDDM after allowing for the effects of sex and age. Results: UCa/Cr (difference -0.10, 95% confidence interval (CI) -0.19 to -0.01; p = 0.03) and UMg/Cr (difference -0.15, 95% CI -0.22 to -0.08; p

Original language	English
Pages (from-to)	F332-F336
Journal	Archives of Disease in Childhood: Fetal and Neonatal Edition
Volume	90
Issue number	4
DOIs	https://doi.org/10.1136/adc.2004.052795
Publication status	Published - Jul 2005

Keywords

Adolescent
Anthropometry
urine: Calcium
administration & dosage: Calcium, Dietary
Child
Child, Preschool
urine: Creatinine
Cross-Sectional Studies
Diabetes Mellitus, Type 1
administration & dosage: Dietary Proteins
Female
Humans
embryology: Kidney
administration & dosage: Magnesium
Male
Pregnancy
Pregnancy in Diabetics
Prenatal Exposure Delayed Effects
Research Support, Non-U.S. Gov't
administration & dosage: Sodium, Dietary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/adc.2004.052795

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@article{38565d7289ac43fb8e280e659cfa0526,

title = "Intrauterine programming of urinary calcium and magnesium excretion in children born to mothers with insulin dependent diabetes mellitus",

abstract = "Background: Offspring of diabetic rats have reduced urinary calcium and magnesium excretion compared with offspring of controls; these differences persist up to 16 weeks after birth, a time equivalent to young adulthood in humans. Objectives: To test the hypothesis that urinary calcium and magnesium excretion would be lower in children born to mothers with insulin dependent diabetes mellitus (ChMIDDM) than those born to nondiabetic mothers. Methods: Concentrations of calcium, magnesium, sodium, and creatinine were measured in first void spot urine samples collected from 45 (28 male; median age 9.6 years) ChMIDDM and 127 (58 male; median age 11.3 years) controls. Analysis of covariance was used to test for differences in urinary calcium to creatinine ratios (UCa/Cr), magnesium to creatinine ratios (UMg/Cr), and log sodium to creatinine ratios (logUNa/Cr) between controls and ChMIDDM after allowing for the effects of sex and age. Results: UCa/Cr (difference -0.10, 95% confidence interval (CI) -0.19 to -0.01; p = 0.03) and UMg/Cr (difference -0.15, 95% CI -0.22 to -0.08; p",

keywords = "Adolescent, Anthropometry, urine: Calcium, administration & dosage: Calcium, Dietary, Child, Child, Preschool, urine: Creatinine, Cross-Sectional Studies, Diabetes Mellitus, Type 1, administration & dosage: Dietary Proteins, Female, Humans, embryology: Kidney, administration & dosage: Magnesium, Male, Pregnancy, Pregnancy in Diabetics, Prenatal Exposure Delayed Effects, Research Support, Non-U.S. Gov't, administration & dosage: Sodium, Dietary",

author = "Mughal, {M. Z.} and Eelloo, {J. A.} and Roberts, {S. A.} and S. Sibartie and M. Maresh and Sibley, {C. P.} and Adams, {J. E.}",

year = "2005",

month = jul,

doi = "10.1136/adc.2004.052795",

language = "English",

volume = "90",

pages = "F332--F336",

journal = "Archives of Disease in Childhood: Fetal and Neonatal Edition",

issn = "1359-2998",

publisher = "BMJ ",

number = "4",

}

TY - JOUR

T1 - Intrauterine programming of urinary calcium and magnesium excretion in children born to mothers with insulin dependent diabetes mellitus

AU - Mughal, M. Z.

AU - Eelloo, J. A.

AU - Roberts, S. A.

AU - Sibartie, S.

AU - Maresh, M.

AU - Sibley, C. P.

AU - Adams, J. E.

PY - 2005/7

Y1 - 2005/7

N2 - Background: Offspring of diabetic rats have reduced urinary calcium and magnesium excretion compared with offspring of controls; these differences persist up to 16 weeks after birth, a time equivalent to young adulthood in humans. Objectives: To test the hypothesis that urinary calcium and magnesium excretion would be lower in children born to mothers with insulin dependent diabetes mellitus (ChMIDDM) than those born to nondiabetic mothers. Methods: Concentrations of calcium, magnesium, sodium, and creatinine were measured in first void spot urine samples collected from 45 (28 male; median age 9.6 years) ChMIDDM and 127 (58 male; median age 11.3 years) controls. Analysis of covariance was used to test for differences in urinary calcium to creatinine ratios (UCa/Cr), magnesium to creatinine ratios (UMg/Cr), and log sodium to creatinine ratios (logUNa/Cr) between controls and ChMIDDM after allowing for the effects of sex and age. Results: UCa/Cr (difference -0.10, 95% confidence interval (CI) -0.19 to -0.01; p = 0.03) and UMg/Cr (difference -0.15, 95% CI -0.22 to -0.08; p

AB - Background: Offspring of diabetic rats have reduced urinary calcium and magnesium excretion compared with offspring of controls; these differences persist up to 16 weeks after birth, a time equivalent to young adulthood in humans. Objectives: To test the hypothesis that urinary calcium and magnesium excretion would be lower in children born to mothers with insulin dependent diabetes mellitus (ChMIDDM) than those born to nondiabetic mothers. Methods: Concentrations of calcium, magnesium, sodium, and creatinine were measured in first void spot urine samples collected from 45 (28 male; median age 9.6 years) ChMIDDM and 127 (58 male; median age 11.3 years) controls. Analysis of covariance was used to test for differences in urinary calcium to creatinine ratios (UCa/Cr), magnesium to creatinine ratios (UMg/Cr), and log sodium to creatinine ratios (logUNa/Cr) between controls and ChMIDDM after allowing for the effects of sex and age. Results: UCa/Cr (difference -0.10, 95% confidence interval (CI) -0.19 to -0.01; p = 0.03) and UMg/Cr (difference -0.15, 95% CI -0.22 to -0.08; p

KW - Adolescent

KW - Anthropometry

KW - urine: Calcium

KW - administration & dosage: Calcium, Dietary

KW - Child

KW - Child, Preschool

KW - urine: Creatinine

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 1

KW - administration & dosage: Dietary Proteins

KW - Female

KW - Humans

KW - embryology: Kidney

KW - administration & dosage: Magnesium

KW - Male

KW - Pregnancy

KW - Pregnancy in Diabetics

KW - Prenatal Exposure Delayed Effects

KW - Research Support, Non-U.S. Gov't

KW - administration & dosage: Sodium, Dietary

U2 - 10.1136/adc.2004.052795

DO - 10.1136/adc.2004.052795

M3 - Article

SN - 1359-2998

VL - 90

SP - F332-F336

JO - Archives of Disease in Childhood: Fetal and Neonatal Edition

JF - Archives of Disease in Childhood: Fetal and Neonatal Edition

IS - 4

ER -

Intrauterine programming of urinary calcium and magnesium excretion in children born to mothers with insulin dependent diabetes mellitus

Abstract

Keywords

UN SDGs

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